The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers.
The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers.
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DOI：
10.3389/fnhum.2014.00204
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发表时间：
2014
影响因子：
2.9
通讯作者：
Carhart-Harris RL
中科院分区：
文献类型：
--
作者：
Roseman L;Leech R;Feilding A;Nutt DJ;Carhart-Harris RL
扰乱一个系统并观察其后果是理解一种现象的经典科学策略。致幻剂以一种显著而新颖的方式扰乱意识，因此是研究其机制的有力工具。在当前的分析中，我们测量了不同独立成分分析（ICA）衍生的静息状态网络（RSNs）的标准模板在两种不同的精神活性药物（兴奋剂/迷幻药混合物MDMA和经典迷幻药裸头草碱）的影响下静息状态功能连接（RSFC）的变化。这两种药物都采用安慰剂控制设计，并产生了明显的主观效果，尽管有报告称，在服用裸盖菇素后，意识发生了更深刻的变化。裸盖菇素作用下，网络间RSFC普遍升高，这表明在迷幻状态下，网络之间的分化程度降低。在视觉和感觉运动RSNs之间也观察到RSFC减少。MDMA对网络间RSFC的影响明显不明显，这意味着裸盖菇素作用下观察到的广泛变化可能是经典迷幻药物所独有的，并且与它们对意识的特别深远的影响有关。这里应用的新分析方法可以应用于其他意识状态的改变，以提高我们对不同意识状态的表征，并最终促进我们对其背后的大脑机制的理解。
Perturbing a system and observing the consequences is a classic scientific strategy for understanding a phenomenon. Psychedelic drugs perturb consciousness in a marked and novel way and thus are powerful tools for studying its mechanisms. In the present analysis, we measured changes in resting-state functional connectivity (RSFC) between a standard template of different independent components analysis (ICA)-derived resting state networks (RSNs) under the influence of two different psychoactive drugs, the stimulant/psychedelic hybrid, MDMA, and the classic psychedelic, psilocybin. Both were given in placebo-controlled designs and produced marked subjective effects, although reports of more profound changes in consciousness were given after psilocybin. Between-network RSFC was generally increased under psilocybin, implying that networks become less differentiated from each other in the psychedelic state. Decreased RSFC between visual and sensorimotor RSNs was also observed. MDMA had a notably less marked effect on between-network RSFC, implying that the extensive changes observed under psilocybin may be exclusive to classic psychedelic drugs and related to their especially profound effects on consciousness. The novel analytical approach applied here may be applied to other altered states of consciousness to improve our characterization of different conscious states and ultimately advance our understanding of the brain mechanisms underlying them.
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影响因子：
3.7
作者：
Kanamaru T;Fujii H;Aihara K
通讯作者：
Aihara K
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
2.5
作者：
Kolbrich, Erin A.;Goodwin, Robert S.;Huestis, Marilyn A.
通讯作者：
Huestis, Marilyn A.
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM