Current and promising pharmacotherapeutic options for candidiasis.
Current and promising pharmacotherapeutic options for candidiasis.
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DOI：
10.1080/14656566.2021.1873951
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发表时间：
2021-05
影响因子：
3.2
通讯作者：
Mylonakis E
中科院分区：
文献类型：
--
作者：
Scorzoni L;Fuchs BB;Junqueira JC;Mylonakis E
Candida spp. are commensal yeasts capable of causing a wide range of infections such as superficial, oral, vaginal, or even systemic infections. Despite medical advances, the antifungal pharmacopeia remains limited and the development of alternative strategies is needed. The authors discuss available treatments for Candida spp. infections, highlighting advantages and limitations related to pharmacokinetics, cytotoxicity, and antimicrobial resistance. Moreover, they present new perspectives to improve the activity of the available antifungals, discussing their immunomodulatory potential and advances on drug delivery carriers. Several new therapeutic approaches are presented including recent synthesized antifungal compounds; drug repurposing using a diversity of antibacterial, antiviral and non-antimicrobial drugs; combination therapies with different compounds or photodynamic therapy; and finally innovations based on nano-particulate delivery systems. With the lack of novel drugs, the available assets must be leveraged to their best advantage through modifications that enhance delivery, efficacy, and solubility. However, these efforts are met with continuous challenges presented by microbes in their infinite plight to resist and survive therapeutic drugs. The pharmacotherapeutic options in development need to focus on new antimicrobial targets. The success of each antimicrobial agent brings strategic insights to the next phased approach in treating Candida spp. infections.
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