Direct hemoperfusion with polymyxin B-immobilized fiber improves shock and hypoxemia during endotoxemia in anesthetized sheep
Direct hemoperfusion with polymyxin B-immobilized fiber improves shock and hypoxemia during endotoxemia in anesthetized sheep
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多粘菌素 B 固定纤维直接血液灌流可改善麻醉羊内毒素血症期间的休克和低氧血症
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
T. Honda
中科院分区：
文献类型：
--
作者：
Hiroshi Yamamoto;T. Koizumi;T. Kaneki;K. Fujimoto;K. Kubo;T. Honda
本研究评价了使用多粘菌素B固定纤维（PMX-F）作为体外血液过滤器的直接血液灌流（DHP）对内毒素血症期间全身性低血压和肺损伤的影响。将绵羊麻醉，插管，用50%氧气机械通气，并在右股动脉和左颈静脉之间连接到DHP系统。第1组（n = 6）绵羊在30 min内输注10 μg/kg大肠杆菌内毒素。同时，绵羊以60 ml/h的流速接受PMX-F（Toraymyxin®：PMX-20 R）DHP 2 h。第2组（n = 6）绵羊输注相同剂量的内毒素，并以与第1组相同的方式用假柱处理。DHP与PMX-F显著改善和恢复了第1组绵羊的全身压力和动脉氧分压，尽管这些值从未恢复到第2组绵羊的基线水平。内毒素输注后，两组均出现肺动脉高压和白细胞减少，但这些数值之间无显著差异。DHP与PMX-F显着降低血浆一氧化氮产物的升高。PMX-F治疗可改善内毒素血症期间的休克和氧合恶化，这可能是通过抑制一氧化氮的产生。
This study evaluates the effect of direct hemoperfusion (DHP) using polymyxin B-immobilized fibers (PMX-F) as an extracorporeal blood filter on systemic hypotension and lung injury during endotoxemia. Sheep were anesthetized, intubated, mechanically ventilated with 50% oxygen and connected to the DHP system between the right femoral artery and left jugular vein. Group 1 (n = 6) sheep were infused with 10 μg/kg Escherichia coli endotoxin over a 30 min period. At the same time, sheep underwent DHP with PMX-F (Toraymyxin®: PMX-20R) for 2 h at a flow rate of 60 ml/h. Group 2 (n = 6) sheep were infused with the same dose of endotoxin and treated with a sham column, in the same manner as those in group 1. DHP with PMX-F significantly improved and restored systemic pressure and arterial oxygen tension in group 1 sheep, although these values never returned to the baseline levels of group 2 sheep. Pulmonary hypertension and leukocytopenia were observed after endotoxin infusion in both groups, but there were no significant differences between these values. DHP with PMX-F significantly decreased the elevation of plasma nitric oxide products. The treatment with PMX-F improves shock and deteriorated oxygenation during endotoxemia, probably through the suppression of nitric oxide production.
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DOI：
10.1164/arrd.1986.134.1.12
发表时间：
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期刊：
The American review of respiratory disease
影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
The American review of respiratory disease
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作者：
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DOI：
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发表时间：
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影响因子：
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