A DTI-based tractography study of effects on brain structure associated with prenatal alcohol exposure in newborns.
A DTI-based tractography study of effects on brain structure associated with prenatal alcohol exposure in newborns.
复制标题
基于DTI的片段学研究了对新生儿中与产前酒精暴露有关的大脑结构的影响。
DOI：
10.1002/hbm.22620
复制
发表时间：
2015-01
影响因子：
4.8
通讯作者：
Meintjes, Ernesta M.
中科院分区：
文献类型：
--
作者：
Taylor, Paul A.;Jacobson, Sandra W.;van der Kouwe, Andre;Molteno, Christopher D.;Chen, Gang;Wintermark, Pia;Alhamud, Alkathafi;Jacobson, Joseph L.;Meintjes, Ernesta M.
Prenatal alcohol exposure is known to have severe, long-term consequences for brain and behavioral development already detectable in infancy and childhood. Resulting features of fetal alcohol spectrum disorders (FASD) include cognitive and behavioral effects, as well as facial anomalies and growth deficits. Diffusion tensor imaging (DTI) and tractography were used to analyze white matter development in 11 newborns (age since conception <45 weeks) whose mothers were recruited during pregnancy. Comparisons were made with 9 age-matched controls born to abstainers or light drinkers from the same Cape Coloured (mixed ancestry) community near Cape Town, South Africa. DTI parameters, T1 relaxation time, proton density and volumes were used to quantify and investigate group differences in white matter (WM) in the newborn brains. Probabilistic tractography was used to estimate and to delineate similar tract locations among the subjects for transcallosal pathways, cortico-spinal projection fibers and cortico-cortical association fibers. In each of these WM networks, the axial diffusivity AD was the parameter that showed the strongest association with maternal drinking. The strongest relations were observed in medial and inferior WM, regions in which the myelination process typically begins. In contrast to studies of older individuals with prenatal alcohol exposure, FA did not exhibit a consistent and significant relation with alcohol exposure. To our knowledge, this is the first DTI-tractography study of prenatally alcohol exposed newborns.
登录
查看更多内容
影响因子：
3.4
作者：
Guerri, C;Pascual, M;Renau-Piqueras, J
通讯作者：
Renau-Piqueras, J
DOI：
10.1111/j.1530-0277.1996.tb01653.x
发表时间：
1996-04-01
影响因子：
3.2
作者：
Jacobson, JL;Jacobson, SW;Sokol, RJ
通讯作者：
Sokol, RJ
影响因子：
5.7
作者：
Bookstein, FL;Streissguth, AP;Barr, HM
通讯作者：
Barr, HM
影响因子：
3.3
作者：
Deoni, SCL;Peters, TM;Rutt, BK
通讯作者：
Rutt, BK
影响因子：
5.7
作者：
Fischl, B;Salat, DH;Dale, AM
通讯作者：
Dale, AM