Hydrodynamic focusing--a versatile tool.
Hydrodynamic focusing--a versatile tool.
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DOI：
10.1007/s00216-011-5415-3
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发表时间：
2012-01
影响因子：
4.3
通讯作者：
Ligler, Frances S.
中科院分区：
文献类型：
--
作者：
Golden, Joel P.;Justin, Gusphyl A.;Nasir, Mansoor;Ligler, Frances S.
微通道中流体动力学聚焦的控制激发了用于微流体混合、分离、传感器、细胞分析和微加工的新方法。实现聚焦和聚焦流体之间的平坦界面取决于雷诺数和装置几何形状，并且许多流体动力学聚焦系统可以从这种理解中受益。对于需要特定横截面形状用于聚焦流的应用，由通道壁中的凹槽结构产生的平流可用于限定聚焦流的形状。可以操纵聚焦流和聚焦流的相对流速以控制聚焦流的横截面积。这份手稿讨论了定义聚焦和聚焦流体之间界面形状的原则，并提供了我们实验室的例子，这些例子使用基于阻抗的传感器，流式细胞术和微加工的流体动力学聚焦，以说明将新功能引入微流体系统的机会的广度。我们评估每个例子的优点和局限性不可或缺的利用流体动力聚焦的特定应用。
The control of hydrodynamic focusing in a microchannel has inspired new approaches for microfluidic mixing, separations, sensors, cell analysis and microfabrication. Achieving a flat interface between the focusing and focused fluids is dependent on Reynolds number and device geometry, and many hydrodynamic focusing systems can benefit from this understanding. For applications where a specific cross-sectional shape is desired for the focused flow, advection generated by grooved structures in the channel walls can be used to define the shape of the focused flow. Relative flow rates of the focused flow and focusing streams can be manipulated to control the crosssectional area of the focused flows. This manuscript discusses the principles for defining the shape of the interface between the focused and focusing fluids and provides examples from our lab that use hydrodynamic focusing for impedance-based sensors, flow cytometry, and microfabrication to illustrate the breadth of opportunities for introducing new capabilities into microfluidic systems. We evaluate each example for the advantages and limitations integral to utilization of hydrodynamic focusing for that particular application.
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使用凹槽生成的护套流量的多波长微流动仪。
影响因子：
6.1
作者：
Golden JP;Kim JS;Erickson JS;Hilliard LR;Howell PB;Anderson GP;Nasir M;Ligler FS
通讯作者：
Ligler FS
影响因子：
7.4
作者：
Kim, Jason S.;Anderson, George P.;Erickson, Jeffrey S.;Golden, Joel P.;Nasir, Mansoor;Ligler, Frances S.
通讯作者：
Ligler, Frances S.
影响因子：
7.4
作者：
Hofmann, O;Voirin, G;Manz, A
通讯作者：
Manz, A
影响因子：
6.1
作者：
Gawad, S;Schild, L;Renaud, P
通讯作者：
Renaud, P
影响因子：
6.1
作者：
Howell, Peter B., Jr.;Golden, Joel P.;Ligler, Frances S.
通讯作者：
Ligler, Frances S.