Metabolic profile of antipsychotic-naive individuals with non-affective psychosis.
Metabolic profile of antipsychotic-naive individuals with non-affective psychosis.
复制标题
DOI：
10.1192/bjp.bp.108.052605
复制
发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Kirkpatrick B
中科院分区：
文献类型：
--
作者：
Fernandez-Egea E;Bernardo M;Donner T;Conget I;Parellada E;Justicia A;Esmatjes E;Garcia-Rizo C;Kirkpatrick B
一些研究表明，精神分裂症患者在使用抗精神病药物之前患糖尿病的风险会增加。小样本量和高皮质醇血症造成混淆的可能性降低了人们对这些结果的信心。旨在检查新诊断、未曾服用抗精神病药物的非情感性精神病患者的糖尿病相关因素。患有精神病的参与者（精神病组；n = 50）和匹配的对照组（对照组；n = 50）接受了 2 小时口服葡萄糖耐量测试。还测定了脂联素、白细胞介素 6 和 C 反应蛋白的空腹浓度。与对照组相比，精神病组的2小时血糖和白细胞介素6浓度以及糖耐量异常的患病率显着升高（精神病组为16%，对照组为0%）。脂联素和 C 反应蛋白浓度在两组之间没有显着差异。这些发现不能归因于皮质醇浓度、吸烟、性别、居住地、体重指数、有氧运动、种族、社会经济地位或年龄的差异。患有非情感性精神病的个体在抗精神病药物治疗之前似乎糖耐量异常以及相关炎症分子异常的患病率增加。这些潜在的问题可能会导致抗精神病药物的代谢副作用。
Some studies suggest individuals with schizophrenia have an increased risk of diabetes prior to antipsychotic use. Small sample sizes and the potential for confounding by hypercortisolaemia have decreased confidence in those results. To examine diabetes-related factors in newly diagnosed, antipsychotic-naive people with non-affective psychosis. Participants with psychosis (the psychosis group; n = 50) and matched controls (the control group; n = 50) were given a 2 h oral glucose tolerance test. Fasting concentrations were also determined for adiponectin, interleukin-6 and C-reactive protein. Compared with the control group, the psychosis group had significant increases in 2 h glucose and interleukin-6 concentrations, and in the prevalence of abnormal glucose tolerance (16% of psychosis group v. 0% of control group). Adiponectin and C-reactive protein concentrations did not differ significantly between the two groups. These findings could not be attributed to differences in cortisol concentrations, smoking, gender, neighbourhood of residence, body mass index, aerobic conditioning, ethnicity, socioeconomic status or age. Individuals with non-affective psychosis appear to have an increased prevalence of abnormal glucose tolerance prior to antipsychotic treatment, as well as abnormalities in a related inflammatory molecule. These underlying problems may contribute to the metabolic side-effects of antipsychotic medications.
登录
查看更多内容
影响因子：
10.4
作者：
Osmond C;Barker DJ
通讯作者：
Barker DJ
影响因子：
3.5
作者：
Tai, ES;Lim, SC;Tan, CE
通讯作者：
Tan, CE
影响因子：
168.9
作者：
Ravelli, ACJ;van der Meulen, JHP;Bleker, OP
通讯作者：
Bleker, OP
影响因子：
2.8
作者：
Haffner, SM
通讯作者：
Haffner, SM
DOI：
10.1177/070674370605100608
发表时间：
2006-05-01
影响因子：
4
作者：
Cohn, Tony A.;Remington, Gary;Wolever, Thomas M. S.
通讯作者：
Wolever, Thomas M. S.