Asthma prevalence, lung and cardiovascular function in adolescents born preterm.
Asthma prevalence, lung and cardiovascular function in adolescents born preterm.
复制标题
DOI：
10.1038/s41598-020-76614-0
复制
发表时间：
2020-11-12
影响因子：
4.6
通讯作者：
Garcia-Garcia ML
中科院分区：
文献类型：
--
作者：
Arroyas M;Calvo C;Rueda S;Esquivias M;Gonzalez-Menchen C;Gonzalez-Carrasco E;Garcia-Garcia ML
我们的主要目的是研究后表面活性物质时代早产青少年的呼吸演变和心肺功能。观察性横断面研究，比较极早产（< 32周）和中晚期早产青少年（≥ 32周）（每组74例）。我们记录了呼吸道症状、肺功能测定和功能性超声心动图。极早产青少年需要更多的呼吸道入院（45.9% vs. 28.4%）（p = 0.03，OR 2.1，CI 95% 1.1-4.2），并且患有更多的当前哮喘（21.6% vs. 9.5%，p = 0.04，OR 2.3，CI 95% 1.1-5.2）。宫内生长受限（IUGR）早产受试者的FEV 1较低（88.7 ± 13.9 vs. 95.9 ± 13.3，p = 0.027），FVC较低（88.2 ± 13.6 vs. 95.5 ± 13.3，p = 0.025）。当评估右心室时，极早产儿显示出更大的E/E'比（p = 0.02）和更长的心肌工作指数（MPI）（p = 0.001）。IUGR青少年的短轴缩短分数（p = 0.016）、E/E′比值（p = 0.029）和MPI（p = 0.06）较长。在左心室方面，极早产儿的E′波速度较低（p = 0.03），E/E′比值较大（p = 0.005），MPI较长（p < 0.001）。孕龄< 32周与青春期哮喘独立相关。13-14岁早产儿需要更多的呼吸入院，双心室舒张功能和整体功能较差。无论胎龄如何，IUGR是早产青少年肺功能较差的危险因素。
Our main objective was to study respiratory evolution and pulmonary and cardiac function in adolescents born preterm in the post-surfactant era. Observational cross-sectional study, comparing very preterm (< 32 weeks) and moderately-late preterm adolescents (≥ 32 weeks) (74 each group). We recorded respiratory symptoms, spirometry and functional echocardiogram. Very preterm adolescents required more respiratory admissions (45.9% vs. 28.4%) (p = 0.03, OR 2.1, CI95% 1.1–4.2) and had more current asthma (21.6% vs. 9.5%, p = 0.04, OR 2.3, CI95% 1.1–5.2). Preterm subjects with intrauterine growth restriction (IUGR) presented lower FEV1 (88.7 ± 13.9 vs. 95.9 ± 13.3, p = 0.027) and lower FVC (88.2 ± 13.6 vs. 95.5 ± 13.3, p = 0.025). When assessing right ventricle, very preterm showed a greater E/E’ ratio (p = 0.02) and longer myocardial performance index (MPI) (p = 0.001). Adolescents with IUGR showed less shortening fraction (p = 0.016), worse E/E′ ratio (p = 0.029) and longer MPI (p = 0.06). Regarding left ventricle, very preterm showed less E′ wave velocity (p = 0.03), greater E/E′ ratio (p = 0.005) and longer MPI (p < 0.001). Gestational age < 32 weeks is independently associated with current asthma in adolescence. Children 13–14 years old born very preterm required more respiratory admissions and had poorer diastolic and global function of both ventricles. IUGR is a risk factor for poorer lung function in preterm adolescents, regardless gestational age.
登录
查看更多内容
DOI：
10.1164/rccm.201412-2142pp
发表时间：
2015-07-15
影响因子：
24.7
作者：
Islam, Jessica Y.;Keller, Roberta L.;Moore, Paul E.
通讯作者：
Moore, Paul E.
影响因子：
14.2
作者：
den Dekker, Herman T.;Voort, Agnes M. M. Sonnenschein-van der;Duijts, Liesbeth
通讯作者：
Duijts, Liesbeth
影响因子：
10
作者：
Doyle, Lex W.;Adams, Anne-Marie;Cheong, Jeanie L.
通讯作者：
Cheong, Jeanie L.
影响因子：
24.3
作者：
Greenough, A;Yuksel, B;Cheeseman, P
通讯作者：
Cheeseman, P
影响因子：
37.8
作者：
Crispi, Fatima;Bijnens, Bart;Gratacos, Eduard
通讯作者：
Gratacos, Eduard