Adaptive Boosting (AdaBoost)-based multiwavelength spatial frequency domain imaging and characterization for ex vivo human colorectal tissue assessment.
Adaptive Boosting (AdaBoost)-based multiwavelength spatial frequency domain imaging and characterization for ex vivo human colorectal tissue assessment.
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DOI：
10.1002/jbio.201960241
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发表时间：
2020-06
影响因子：
2.8
通讯作者：
Zhu Q
中科院分区：
文献类型：
--
作者：
Li S;Zeng Y;Chapman WC Jr;Erfanzadeh M;Nandy S;Mutch M;Zhu Q
目前诊断结直肠癌的金标准测试仍然是活检标本中腔内肿瘤的组织学检查。然而，活检部位的选择需要对肠道进行目视检查，通常使用白光内窥镜。因此，这种技术不太适合检测小的或无害的病变。我们假设另一种方式-多波长空间频域成像(SFDI) -将能够区分各种结直肠肿瘤与正常组织。在人类结直肠组织的离体研究中，我们报告了正常、腺瘤性息肉和癌症标本的光学吸收和散射特征。训练异常与正常自适应增强（AdaBoost）分类器，基于SFDI成像特征对组织进行二分类，实现了受试者工作特征（ROC）曲线下面积（AUC） 0.95。我们得出结论，基于adaboost的多波长SFDI可以区分异常和正常的结肠组织，未来可能会改善远端胃肠道的腔内筛查。
The current gold standard diagnostic test for colorectal cancer remains histological inspections of endoluminal neoplasia in biopsy specimens. However, biopsy site selection requires visual inspection of the bowel, typically with a white-light endoscope. Therefore, this technique is poorly suited to detect small or innocuous-appearing lesions. We hypothesize that an alternative modality—multiwavelength spatial frequency domain imaging (SFDI)—would be able to differentiate various colorectal neoplasia from normal tissue. In this ex vivo study of human colorectal tissues, we report the optical absorption and scattering signatures of normal, adenomatous polyp and cancer specimens. An abnormal vs. normal adaptive boosting (AdaBoost) classifier is trained to dichotomize tissue based on SFDI imaging characteristics, and an area under the receiver operating characteristic (ROC) curve (AUC) of 0.95 is achieved. We conclude that AdaBoost-based multiwavelength SFDI can differentiate abnormal from normal colorectal tissues, potentially improving endoluminal screening of the distal gastrointestinal tract in the future.
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影响因子：
13.5
作者：
Chan, Jonathan Cheung-Wai;Paelinckx, Desire
通讯作者：
Paelinckx, Desire
影响因子：
3.4
作者：
Vervandier, Jean;Gioux, Sylvain
通讯作者：
Gioux, Sylvain
影响因子：
3.5
作者：
Cuccia DJ;Bevilacqua F;Durkin AJ;Ayers FR;Tromberg BJ
通讯作者：
Tromberg BJ
影响因子：
3.4
作者：
Iftimia N;Iyer AK;Hammer DX;Lue N;Mujat M;Pitman M;Ferguson RD;Amiji M
通讯作者：
Amiji M
DOI：
10.1186/bcr3455
发表时间：
2013
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Laughney AM;Krishnaswamy V;Rizzo EJ;Schwab MC;Barth RJ Jr;Cuccia DJ;Tromberg BJ;Paulsen KD;Pogue BW;Wells WA
通讯作者：
Wells WA