Skeletal muscle fat in individuals with rheumatoid arthritis compared to healthy adults.
Skeletal muscle fat in individuals with rheumatoid arthritis compared to healthy adults.
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DOI：
10.1016/j.exger.2019.110768
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发表时间：
2020-01
影响因子：
3.9
通讯作者：
Piva, Sara R.
中科院分区：
文献类型：
--
作者：
Khoja, Samannaaz S.;Patterson, Charity G.;Goodpaster, Bret H.;Delitto, Anthony;Piva, Sara R.
比较类风湿性关节炎（RA）患者与同龄健康人以及比RA患者年长至少10岁的健康人之间的骨骼肌脂肪（SMF）、肌间脂肪组织（IMAT）和皮下脂肪组织（SAT）。两项横向研究。在第一项研究中，RA受试者与健康成年人的年龄，性别和BMI相匹配。在第二项研究中，RA受试者按性别和BMI与10-20岁的成年人相匹配。通过大腿中部区域的计算机断层扫描图像测量SMF、IMAT和SAT。我们使用参数或非参数相关样本检验来比较RA受试者和健康成人之间的脂肪积累。在第一项研究中，RA队列的SMF显著高于年龄匹配的健康对照组（平均差异= −3.5 HU（95% −6.2，−0.9），p=0.011），但两个队列之间的IMAT和SAT相似。在第二项研究中，RA和匹配的老年健康队列之间的SMF、IMAT和SAT无显著差异。在这两项研究中，RA受试者和健康成人之间的大腿中部肌肉面积没有显著差异。RA患者的SMF蓄积高于年龄、性别、BMI相似的健康个体。与匹配的健康老年人相比，RA中肌肉内和周围的脂肪积累没有差异，表明RA中的肌肉脂肪积累可能模仿与健康衰老没有不同的模式。
To compare skeletal muscle fat (SMF), intermuscular adipose tissue (IMAT) and subcutaneous adipose tissue (SAT) between individuals with rheumatoid arthritis (RA), and healthy individuals of the same age, and healthy individuals at least 10 years older than those with RA. Two cross-sectional studies. In the first study, RA subjects were matched by age, sex, and BMI with healthy adults. In the second, RA subjects were matched by sex and BMI to adults 10–20 years older. SMF, IMAT and SAT were measured with computed tomography images of the mid-thigh region. We used parametric or non-parametric related-samples tests to compare fat accumulation between RA subjects and healthy adults. In the first study SMF was significantly higher in the RA cohort compared to their age-matched healthy counterparts (mean difference= −3.5 HU (95% −6.2, −0.9), p=0.011), but IMAT and SAT were similar between cohorts. In the second study, SMF, IMAT and SAT were not significantly different between the RA and matched older healthy cohorts. In both studies, there were no significant differences in mid-thigh muscle area between RA subjects and healthy adults. SMF accumulation in RA was higher than in healthy individuals of similar age, sex, BMI. Accumulation of fat within and around the muscles in RA was not different compared to the matched healthy older individuals, indicating that muscle fat accumulation in RA might mimic a pattern not different from healthy aging.
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影响因子：
4.7
作者：
Baker JF;Von Feldt J;Mostoufi-Moab S;Noaiseh G;Taratuta E;Kim W;Leonard MB
通讯作者：
Leonard MB
影响因子：
3.3
作者：
Goodpaster, BH;Carlson, CL;Newman, AB
通讯作者：
Newman, AB
DOI：
10.1002/art.23719
发表时间：
2008-06-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Giles, Jon T.;Ling, Shari M.;Bathon, Joan M.
通讯作者：
Bathon, Joan M.
影响因子：
5.8
作者：
Goodpaster, BH;He, J;Kelley, DE
通讯作者：
Kelley, DE
影响因子：
5.5
作者：
Hanh-Hung Dao;Quan-Trung Do;Sakamoto, Junichi
通讯作者：
Sakamoto, Junichi