Functional comparison of breast milk, cow milk and goat milk based on changes in the intestinal flora of mice
Functional comparison of breast milk, cow milk and goat milk based on changes in the intestinal flora of mice
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基于小鼠肠道菌群变化的母乳、牛奶和羊奶的功能比较
DOI：
10.1016/j.lwt.2021.111976
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Zhang Fuxin
中科院分区：
文献类型：
--
作者：
Liu Yufang;Cai Junna;Zhang Fuxin
不同物种的牛奶在其主要成分上有所不同。本研究分析了母乳、牛乳和羊奶中主要成分的含量，并利用16 S rRNA基因高通量测序技术评价了其对小鼠肠道菌群的影响。不同类型的牛奶之间观察到营养成分的一些显着差异，这些差异可能会改变小鼠肠道微生物群的组成和功能特征。微生物多样性分析表明，母乳、牛乳、羊奶和对照组肠道菌群组成不同。宏基因组分析显示，母乳组中异普氏菌属和双歧杆菌的相对丰度显著增加，而牛奶组和羊奶组中异球藻属和阿克曼氏菌的相对丰度显著增加（P<0. 001）。牛奶中蛋白质、矿物质和氨基酸总量与阿克曼氏菌呈显著正相关，与双歧杆菌、异普氏菌呈显著负相关。这些表明，母乳、牛奶和山羊奶进入肠道时，不同类型的牛奶之间存在足够的差异，并不同程度地改变肠道微生物群，这可能会对微生物群的生理功能产生积极影响。
Milk from various species differs in their main components. In this study, we analyzed the content of main components in breast milk, cow milk and goat milk, and evaluated their impacts on the intestinal microbiota in mice using the high-throughput sequencing of 16 S rRNA genes. Several significant differences in the nutrient components were observed between different milk types and these differences could alter the composition and functional feature of intestinal microbiota in mice. Microbial diversity analysis indicated that the composition of intestinal microbiota differed between breast milk, cow milk, goat milk and control groups. The metagenomic analysis showed that relative abundance of Alloprevotella and Bifidobacterium significantly increased in breast milk group, while Allobaculum and Akkermansia were significantly enriched in cow milk group and goat milk group, respectively (P<0.001). We also found that protein, minerals and total amino acids of milk were positively correlated with Akkermansia and negatively correlated with Alloprevotella, Bifidobacterium. These suggest that breast milk, cow milk and goat milk enter the intestine with enough variation between types of milk and differentially modify the intestinal microbiota, which may positively affect the physiological function of the microbiota.
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Akkermansia muciniphila 及密切相关物种的比较基因组和功能分析
影响因子：
2.1
作者：
Xing Juyuan;Li Xiaobo;Sun Yingjiao;Zhao Juanjuan;Miao Shaohua;Xiong Qin;Zhang Yonggang;Zhang Guishan
通讯作者：
Zhang Guishan
影响因子：
6.1
作者：
Yuyu Shao;Zhaoxia Wang
通讯作者：
Yuyu Shao;Zhaoxia Wang
影响因子：
--
作者：
Herrmann E;Young W;Rosendale D;Reichert-Grimm V;Riedel CU;Conrad R;Egert M
通讯作者：
Egert M
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.2
作者：
Amer, Bashar;Clausen, Morten Rahr;Dalsgaard, Trine Kastrup
通讯作者：
Dalsgaard, Trine Kastrup