Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease.
Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease.
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DOI：
10.1016/j.jnutbio.2018.04.004
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Palotás A
中科院分区：
文献类型：
--
作者：
Lombardi VC;De Meirleir KL;Subramanian K;Nourani SM;Dagda RK;Delaney SL;Palotás A
肠脑轴是指肠神经系统和中枢神经系统之间的双向通讯。越来越多的证据支持这一前提，即肠道微生物群在其功能中起着关键作用，并导致了更常见，也许更准确的术语肠道-微生物群-脑轴。许多研究已经确定了改变的微生物组与神经免疫和神经炎症疾病之间的联系。在大多数情况下，尚不清楚这些关联是因果关系；尽管如此，维持或恢复微生物群的稳态可能是治疗或预防这些疾病的未来机会。近年来，一些研究已经确定饮食是塑造肠道微生物群组成的主要因素，反过来，粘膜和全身免疫系统。在这篇综述中，我们将讨论通过饮食和营养来改变和塑造微生物群以治疗或预防神经免疫和神经炎症疾病的潜在机遇和挑战。
The gut-brain-axis refers to the bidirectional communication between the enteric nervous system and the central nervous system. Mounting evidence supports the premise that the intestinal microbiota plays a pivotal role in its function and has led to the more common and perhaps more accurate term gut-microbiota-brain axis. Numerous studies have identified associations between an altered microbiome and neuroimmune and neuroinflammatory diseases. In most cases, it is unknown if these associations are cause or effect; notwithstanding, maintaining or restoring homeostasis of the microbiota may represent future opportunities when treating or preventing these diseases. In recent years, several studies have identified the diet as a primary contributing factor in shaping the composition of the gut microbiota, and in turn, the mucosal and systemic immune systems. In this review, we will discuss the potential opportunities and challenges with respect to modifying and shaping the microbiota through diet and nutrition in order to treat or prevent neuroimmune and neuroinflammatory disease.
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影响因子：
3.1
作者：
Braam, Wiebe;Ehrhart, Friederike;Curfs, Leopold
通讯作者：
Curfs, Leopold
DOI：
10.1007/978-1-4939-0897-4_17
发表时间：
2014-01-01
期刊：
MICROBIAL ENDOCRINOLOGY: THE MICROBIOTA-GUT-BRAIN AXIS IN HEALTH AND DISEASE
影响因子：
--
作者：
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通讯作者：
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影响因子：
4
作者：
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通讯作者：
Stanton, C.
影响因子：
7.4
作者：
Beaumont, Martin;Andriamihaja, Mireille;Blachier, Francois
通讯作者：
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影响因子：
64.8
作者：
Baumler, Andreas J.;Sperandio, Vanessa
通讯作者：
Sperandio, Vanessa