Roles of myocardial blood volume and flow in coronary artery disease: an experimental MRI study at rest and during hyperemia.
Roles of myocardial blood volume and flow in coronary artery disease: an experimental MRI study at rest and during hyperemia.
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心肌血容量和流量在冠状动脉疾病中的作用：静息和充血期间的实验性 MRI 研究。
DOI：
10.1007/s00330-010-1740-8
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发表时间：
2010-08
影响因子：
5.9
通讯作者：
Zheng, Jie
中科院分区：
文献类型：
--
作者：
McCommis, Kyle S.;Goldstein, Thomas A.;Abendschein, Dana R.;Misselwitz, Bernd;Pilgram, Thomas;Gropler, Robert J.;Zheng, Jie
验证冠状动脉狭窄情况下的快速灌注图技术，并进一步评估绝对心肌血容量 (MBV) 和血流量 (MBF) 与整体心肌需氧量的关系。一组 27 只杂种狗被分为 10 只对照组和 17 只患有急性冠状动脉狭窄的狗。在 1.5-T MRI 上，通过快速注射血池造影剂进行首过灌注成像，以确定静息时以及双嘧达莫诱导的血管舒张或多巴酚丁胺诱导的应激期间的心肌灌注。 MBF 和 MBV 的区域值通过使用快速绘图技术进行量化。注射彩色微球和99mTc标记的红细胞以获得各自的金标准。微球测量的 MBF 和 99mTc 测量的 MBV 参考值与 MR 结果相关良好。鉴于 MBF 的变化相同，多巴酚丁胺的 MBV 变化是双嘧达莫的两倍。在多巴酚丁胺应激下，MBV 与心肌总需氧量的相关性比 MBF 更好。在狭窄严重程度增加的情况下，冠状动脉狭窄逐渐减少这种关联。 MR首过灌注可以快速估计局部MBF和MBV。与心肌灌注的标准定性临床评估相比，MBV 的绝对定量可能会增加有关狭窄严重程度和心肌活力的额外信息。
To validate fast perfusion mapping techniques in a setting of coronary artery stenosis, and to further assess the relationship of absolute myocardial blood volume (MBV) and blood flow (MBF) to global myocardial oxygen demand. A group of 27 mongrel dogs were divided into 10 controls and 17 with acute coronary stenosis. On 1.5-T MRI, first-pass perfusion imaging with a bolus injection of a blood-pool contrast agent was performed to determine myocardial perfusion both at rest and during either dipyridamole-induced vasodilation or dobutamine-induced stress. Regional values of MBF and MBV were quantified by using a fast mapping technique. Color microspheres and 99mTc-labeled red blood cells were injected to obtain respective gold standards. Microsphere-measured MBF and 99mTc-measured MBV reference values correlated well with the MR results. Given the same changes in MBF, changes in MBV are twofold greater with dobutamine than with dipyridamole. Under dobutamine stress, MBV shows better association with total myocardial oxygen demand than MBF. Coronary stenosis progressively reduced this association in the presence of increased stenosis severity. MR first-pass perfusion can rapidly estimate regional MBF and MBV. Absolute quantification of MBV may add additional information on stenosis severity and myocardial viability compared with standard qualitative clinical evaluations of myocardial perfusion.
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影响因子：
9.1
作者：
HEYMANN, MA;PAYNE, BD;RUDOLPH, AM
通讯作者：
RUDOLPH, AM
多巴酚丁胺对冠状动脉微循环的直接影响：使用心肌造影超声心动图与腺苷进行比较
DOI：
10.1067/s0894-7317(03)00423-1
发表时间：
2003-08-01
影响因子：
6.5
作者：
Bin, JP;Le, E;Kaul, S
通讯作者：
Kaul, S
影响因子：
10.8
作者：
FUKUYAMA, T;SOBEL, BE;ROBERTS, R
通讯作者：
ROBERTS, R
影响因子：
3.3
作者：
Streif, JUG;Nahrendorf, M;Bauer, WR
通讯作者：
Bauer, WR
影响因子：
19.7
作者：
Waller, C;Kahler, E;Bauer, WR
通讯作者：
Bauer, WR