Case-control study of birth characteristics and the risk of hepatoblastoma.
Case-control study of birth characteristics and the risk of hepatoblastoma.
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DOI：
10.1016/j.canep.2013.03.004
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发表时间：
2013-08
影响因子：
2.6
通讯作者：
Ritz, Beate
中科院分区：
文献类型：
--
作者：
Heck, Julia E.;Meyers, Travis J.;Lombardi, Christina;Park, Andrew S.;Cockburn, Myles;Reynolds, Peggy;Ritz, Beate
关键词：
肝母细胞瘤是一种恶性胚胎肿瘤，通常在五岁以下的儿童中被诊断出来。对肝母细胞瘤的病因知之甚少。我们使用概率记录链接程序将加州癌症登记处1988-2007年间6岁以下儿童诊断为肝母细胞瘤的记录与出生记录进行了匹配，产生了261例病例。对照组(n=218,277)是从加州出生记录中随机选择的，按出生年份与加州同一时期所有癌症病例匹配的频率。我们检查了人口和社会经济信息、出生特征、孕产史、怀孕、分娩和分娩中的并发症，以及与新生儿相关的异常情况和临床程序，研究数据来自出生证明。我们观察到低出生体重[1500-2499克，优势比(OR)=2.02，95%可信区间(CI)1.29-3.15]和极低出生体重(1500克，OR=15.4，95%可信区间10.7-22.3)、早产和低出生体重的儿童患肝母细胞瘤的风险增加。33周(OR=7.27，95%CI 5.00，10.6)、胎龄小(OR=1.75，95%CI 1.25~2.45)、多胎妊娠(OR=2.52，95%CI 1.54~4.14)。我们观察到一些妊娠和分娩并发症与肝母细胞瘤有关，包括先兆子痫、早产、胎儿窘迫和先天性畸形。这些发现证实了先前报道的与低出生体重和先兆子痫的联系。与多胎妊娠的关系此前已有报道，并可能表明与不孕症治疗有关。
Hepatoblastoma is a malignant embryonal tumor typically diagnosed in children younger than five years of age. Little is known on hepatoblastoma etiology. We matched California Cancer Registry records of hepatoblastomas diagnosed in children younger than age 6 from 1988–2007 to birth records using a probabilistic record linkage program, yielding 261 cases. Controls (n=218,277), frequency matched by birth year to all cancer cases in California for the same time period, were randomly selected from California birth records. We examined demographic and socioeconomic information, birth characteristics, pregnancy history, complications in pregnancy, labor and delivery, and abnormal conditions and clinical procedures relating to the newborn, with study data taken from birth certificates. We observed increased risks for hepatoblastoma among children with low [1500–2499 g, Odds Ratio (OR)=2.02, 95% confidence interval (CI) 1.29–3.15] and very low birthweight (<1500 g, OR=15.4, 95% CI 10.7–22.3), preterm birth <33 weeks (OR=7.27, 95% CI 5.00, 10.6), small size for gestational age (OR=1.75, 95% CI 1.25–2.45), and with multiple birth pregnancies (OR=2.52, 95% CI 1.54–4.14). We observed a number of pregnancy and labor complications to be related to hepatoblastoma, including preeclampsia, premature labor, fetal distress, and congenital anomalies. These findings confirm previously reported associations with low birthweight and preeclampsia. The relation with multiple birth pregnancies has been previously reported and may indicate a relation to infertility treatments.
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影响因子：
1.4
作者：
Maruyama, K;Ikeda, H;Tokunaga, Y
通讯作者：
Tokunaga, Y
影响因子：
2.4
作者：
GALIFER, RB;SULTAN, C;BARNEON, G
通讯作者：
BARNEON, G
影响因子：
1.5
作者：
BOTTOMS, S
通讯作者：
BOTTOMS, S
影响因子：
5.1
作者：
DeBaun, MR;Tucker, MA
通讯作者：
Tucker, MA
影响因子：
6.4
作者：
Licht, S. de Fine;Schmidt, L. S.;Schuz, J.
通讯作者：
Schuz, J.