Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions.
Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions.
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DOI：
10.1002/eji.202048909
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发表时间：
2021-10
影响因子：
5.4
通讯作者：
Tait Wojno ED
中科院分区：
文献类型：
--
作者：
Oyesola OO;Tait Wojno ED
2 型免疫对于介导对寄生虫感染的抵抗力的保护和修复反应至关重要。这种免疫反应还会导致特应性疾病期间的异常炎症。前列腺素是一类关键的脂质介质，在 2 型炎症过程中释放，在控制 2 型炎症的起始、激活、维持、效应功能和消退中发挥着不可或缺的作用。在这篇综述中，我们探讨了不同前列腺素家族成员及其在过敏原和蠕虫诱导的 2 型炎症中所结合的受体的作用，以及前列腺素促进或抑制 2 型炎症的机制。此外，我们讨论了蠕虫寄生虫产生的前列腺素在调节宿主-病原体相互作用中的潜在作用，以及前列腺素如何调节蠕虫感染和过敏之间的反向关系。最后，我们讨论了利用我们对前列腺素途径的理解为患有 2 型炎症性疾病的人类开发新的治疗选择的机会，这些炎症性疾病具有显着的前列腺素驱动成分，包括过敏性鼻炎和哮喘。前列腺素是 2 型免疫反应的关键调节剂，该反应是针对寄生虫感染或接触过敏原而发生的。这些生物活性脂质控制 2 型炎症的引发、激活、维持、效应功能和消退，并且可以具有促炎或抗炎作用。因此，宿主或蠕虫产生的前列腺素可用于治疗患有 2 型炎症性疾病的人类。
Type 2 immunity is critical for the protective and repair responses that mediate resistance to parasitic helminth infection. This immune response also drives aberrant inflammation during atopic diseases. Prostaglandins are a class of critical lipid mediators that are released during type 2 inflammation and are integral in controlling the initiation, activation, maintenance, effector functions, and resolution of Type 2 inflammation. In this review, we explore the roles of the different prostaglandin family members and the receptors they bind to during allergen‐ and helminth‐induced Type 2 inflammation and the mechanism through which prostaglandins promote or suppress Type 2 inflammation. Furthermore, we discuss the potential role of prostaglandins produced by helminth parasites in the regulation of host–pathogen interactions, and how prostaglandins may regulate the inverse relationship between helminth infection and allergy. Finally, we discuss opportunities to capitalize on our understanding of prostaglandin pathways to develop new therapeutic options for humans experiencing Type 2 inflammatory disorders that have a significant prostaglandin‐driven component including allergic rhinitis and asthma. Prostaglandins are critical regulators of the Type 2 immune response that occurs in response to parasitic helminth infection or exposure to allergens. These bioactive lipids control the initiation, activation, maintenance, effector functions, and resolution of Type 2 inflammation and can be pro‐ or anti‐inflammatory. As such, prostaglandins produced by hosts or helminth parasites could be targeted to treat humans with Type 2 inflammatory disorders.
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影响因子：
2.5
作者：
Bezencon, C.;Fuerholz, A.;Damak, S.
通讯作者：
Damak, S.
DOI：
10.1016/s1388-1981(99)00164-x
发表时间：
2000-01-17
影响因子：
4.8
作者：
Abramovitz, M;Adam, M;Metters, KM
通讯作者：
Metters, KM
影响因子：
32.4
作者：
Buckley, Christopher D.;Gilroy, Derek W.;Serhan, Charles N.
通讯作者：
Serhan, Charles N.
影响因子：
4.4
作者：
Card, Jeffrey W.;Carey, Michelle A.;Zeldin, Darryl C.
通讯作者：
Zeldin, Darryl C.
影响因子：
10
作者：
Birrell MA;Maher SA;Dekkak B;Jones V;Wong S;Brook P;Belvisi MG
通讯作者：
Belvisi MG