Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects.
Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects.
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DOI：
10.1016/j.tox.2020.152565
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发表时间：
2020-10
期刊：
影响因子：
4.5
通讯作者：
Fenton SE
中科院分区：
文献类型：
--
作者：
Blake BE;Fenton SE
全氟烷基和多氟烷基物质（PFAS）是普遍存在的饮用水污染物，由于越来越多的证据表明与暴露相关的不良健康后果，包括肾功能降低，代谢综合征，甲状腺破坏和不良妊娠结局。自20世纪40年代以来，PFAS已在美国生产，现在包括一个由不同化学部分组成的不断增长的化学家族，但对相对较少的化合物进行了毒理学效应研究。重要的是，在子宫内暴露于一些PFAS与母亲和后代的不良结局相关，例如妊娠高血压疾病（HDP），包括先兆子痫和低出生体重。考虑到HDP、胎盘功能障碍、不良健康结果和成年期慢性疾病风险增加之间的关系，发育和终身暴露于PFAS的作用可能以复杂的方式导致疾病风险。在这里，一些PFAS在甲状腺功能紊乱，肾脏疾病和代谢综合征中的作用的证据是合成的，重点是胎盘作为PFAS和成人疾病编程剂的关键但研究不足的目标。未来的研究工作必须继续填补胎盘对PFAS等环境暴露的敏感性，随后对母亲和儿童的围产期健康风险以及成年后代的潜在健康影响之间的知识空白。
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous drinking water contaminants of concern due to mounting evidence implicating adverse health outcomes associated with exposure, including reduced kidney function, metabolic syndrome, thyroid disruption, and adverse pregnancy outcomes. PFAS have been produced in the U.S. since the 1940s and now encompass a growing chemical family comprised of diverse chemical moieties, yet the toxicological effects have been studied for relatively few compounds. Critically, exposures to some PFAS in utero are associated with adverse outcomes for both mother and offspring, such as hypertensive disorders of pregnancy (HDP), including preeclampsia, and low birth weight. Given the relationship between HDP, placental dysfunction, adverse health outcomes, and increased risk for chronic diseases in adulthood, the role of both developmental and lifelong exposure to PFAS likely contributes to disease risk in complex ways. Here, evidence for the role of some PFAS in disrupted thyroid function, kidney disease, and metabolic syndrome is synthesized with an emphasis on the placenta as a critical yet understudied target of PFAS and programming agent of adult disease. Future research efforts must continue to fill the knowledge gap between placental susceptibility to environmental exposures like PFAS, subsequent perinatal health risks for both mother and child, and latent health effects in adult offspring.
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Fernald 社区队列中纵向血清全氟烷基物质 (PFAS) 水平与甲状腺激素、肾功能和体重指数测量之间的关联。
DOI：
10.1016/j.envpol.2018.07.042
发表时间：
2018-11
期刊：
Environmental pollution (Barking, Essex : 1987)
影响因子：
--
作者：
Blake BE;Pinney SM;Hines EP;Fenton SE;Ferguson KK
通讯作者：
Ferguson KK
影响因子：
6.6
作者：
Alexander, Erik K.;Pearce, Elizabeth N.;Sullivan, Scott
通讯作者：
Sullivan, Scott
影响因子：
4.5
作者：
Bangma J;Szilagyi J;Blake BE;Plazas C;Kepper S;Fenton SE;C Fry R
通讯作者：
C Fry R
DOI：
10.3390/ijerph13010146
发表时间：
2016-01-20
影响因子：
--
作者：
Ashley-Martin J;Dodds L;Arbuckle TE;Morisset AS;Fisher M;Bouchard MF;Shapiro GD;Ettinger AS;Monnier P;Dallaire R;Taback S;Fraser W
通讯作者：
Fraser W
影响因子：
3.3
作者：
Abbott, Barbara D.;Wood, Carmen R.;Lau, Christopher
通讯作者：
Lau, Christopher