Associations between longitudinal serum perfluoroalkyl substance (PFAS) levels and measures of thyroid hormone, kidney function, and body mass index in the Fernald Community Cohort.
Associations between longitudinal serum perfluoroalkyl substance (PFAS) levels and measures of thyroid hormone, kidney function, and body mass index in the Fernald Community Cohort.
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Fernald 社区队列中纵向血清全氟烷基物质 (PFAS) 水平与甲状腺激素、肾功能和体重指数测量之间的关联。
DOI：
10.1016/j.envpol.2018.07.042
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Ferguson KK
中科院分区：
文献类型：
--
作者：
Blake BE;Pinney SM;Hines EP;Fenton SE;Ferguson KK
全氟烷基物质（PFAS）是一类广泛用于各种工业过程和消费品的人造化合物，已在世界各地的人类血清中检测到。先前对人类进行的横断面和队列研究表明，接触PFAS与一系列广泛的慢性疾病有关，包括内分泌紊乱、发育健康影响、癌症和代谢变化。我们检查了一组8个PFAS与甲状腺功能障碍、肾功能和体重指数（BMI）指标之间的关系，所有这些指标都是在研究过程中重复的时间点（1990-2008）测量的。参与者（N=210）是根据来自pfas污染含水层的家庭供水从Fernald社区队列中选择的。在调整后的重复测量模型中，我们观察到血清PFAS与甲状腺激素以及肾小球滤过率（eGFR）测量的肾功能之间存在一些显著的关联。血清全氟辛烷磺酸四分位数（IQR）升高与促甲状腺激素升高9.75% （95% CI= 1.72, 18.4）相关。血清PFNA、PFHxS和PFDeA的IQR增加分别与eGFR的- 1.61% （95% CI= - 3.53, - 0.59）、- 2.06% （95% CI= - 3.53, - 0.59）和- 2.20% （95% CI= - 4.25, - 0.14）变化相关。另一方面，血清Me-PFOSA的IQR升高与eGFR升高1.53% （95% CI= 0.34, 2.73）相关。BMI和血清PFAS无显著相关性。我们的研究结果与先前的报道一致，即血清PFAS与肾脏和甲状腺功能改变有关。
Perfluoroalkyl substances (PFAS) are a diverse class of manufactured compounds used in a wide range of industrial processes and consumer products and have been detected in human serum worldwide. Previous cross-sectional and cohort studies in humans have suggested exposure to PFAS is associated with a wide array of chronic diseases, including endocrine disruption, developmental health effects, cancer and metabolic changes. We examined the associations between a panel of eight PFAS and indicators of thyroid disruption, kidney function, and body mass index (BMI), all of which were measured at repeated time points (1990-2008) over the course of the study. Participants (N=210) were selected from the Fernald Community Cohort based on household water supply from a PFAS-contaminated aquifer. In adjusted repeated measures models, we observed several notable associations between serum PFAS and thyroid hormones as well as kidney function as measured by estimated glomerular filtration rate (eGFR). An interquartile (IQR) increase in serum PFOS was associated with a 9.75% (95% CI= 1.72, 18.4) increase in thyroid stimulating hormone. An IQR increase in serum PFNA, PFHxS, and PFDeA was associated with a −1.61% (95% CI= −3.53, −0.59), −2.06% (95% CI= −3.53, −0.59), and −2.20% (95% CI= −4.25, −0.14) change in eGFR, respectively. On the other hand, an IQR increase in serum Me-PFOSA was associated with a 1.53% (95% CI= 0.34, 2.73) increase in eGFR. No significant associations with BMI and serum PFAS were noted. Our findings are in agreement with previous reports that serum PFAS are associated with altered kidney and thyroid function.
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DOI：
10.1186/1476-069x-13-106
发表时间：
2014-12-10
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
de Cock M;de Boer MR;Lamoree M;Legler J;van de Bor M
通讯作者：
van de Bor M
影响因子：
8.3
作者：
Fisher, Mandy;Arbuckle, Tye E.;Haines, Douglas A.
通讯作者：
Haines, Douglas A.
影响因子：
11.4
作者：
Haug, Line S.;Thomsen, Cathrine;Bechert, Georg
通讯作者：
Bechert, Georg
影响因子：
10.9
作者：
Hu, Xindi C.;Andrews, David Q.;Lindstrom, Andrew B.;Bruton, Thomas A.;Schaider, Laurel A.;Grandjean, Philippe;Lohmann, Rainer;Carignan, Courtney C.;Blum, Arlene;Balan, Simona A.;Higgins, Christopher P.;Sunderland, Elsie M.
通讯作者：
Sunderland, Elsie M.
影响因子：
--
作者：
Basu G;Mohapatra A
通讯作者：
Mohapatra A