Latent profile analysis reveals the central role of psychological symptoms in driving disease severity in chronic constipation.
Latent profile analysis reveals the central role of psychological symptoms in driving disease severity in chronic constipation.
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潜在特征分析揭示了心理症状在导致慢性便秘疾病严重程度方面的核心作用。
DOI：
10.1111/nmo.14773
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发表时间：
2024
影响因子：
3.5
通讯作者：
Burton-Murray,Helen
中科院分区：
文献类型：
--
作者：
Abber,SophieR;Buchanan,KellyL;Clukey,Jenna;Joiner,ThomasE;Staller,Kyle;Burton-Murray,Helen
背景慢性便秘（CC）是以反映异质性生理的症状标准来定义的。然而，许多患者与CC有显着的心理共病，一个替代的定义，使用生物心理社会分类模型可能是必要的，以告知未来的治疗。我们力求：（1）使用潜在特征分析经验性地得出CC患者的心理症状特征，（2）通过比较症状严重程度、GI特异性焦虑、体重指数（BMI）和肛门直肠测压结果来验证这些特征。方法参与者包括接受肛门直肠测压的成年人CC（N= 468，82%女性，法师= 47）。抑郁/焦虑症状和进食障碍（艾德）症状（EAT-26）被用作指标（即，用于导出轮廓的变量）表示独特的心理构造。将便秘症状、GI特异性焦虑、BMI和肛门直肠测压结果用作验证者（即，关键结果5个特征的解决方案提供了最佳的统计拟合，包括以下潜在特征（LP）：LP 1称为“高节食，低贪食”; LP 2称为“高艾德症状”; LP 3称为“中度艾德症状”; LP 4称为“高焦虑和抑郁，低艾德症状”; LP 5称为“低心理症状”。与以较高心理症状（任何类型）为特征的四种特征相比，低心理症状特征（61%的样本）具有较低的腹部和总体便秘严重程度以及较低的GI特异性焦虑。Profiles在BMI或肛门直肠测压结果上没有显著差异。结论和推论在CC成人中，具有高心理症状的Profiles增加了便秘症状的严重程度和GI特异性焦虑。未来的研究应该测试这些特征是否能预测不同的治疗结果。
BackgroundChronic constipation (CC) is defined by symptom criteria reflecting heterogenous physiology. However, many patients with CC have significant psychological comorbidities—an alternative definition using a biopsychosocial classification model could be warranted to inform future treatments. We sought to: (1) empirically derive psychological symptom profiles of patients with CC using latent profile analysis and (2) validate these profiles by comparing them on symptom severity, GI‐specific anxiety, body mass index (BMI), and anorectal manometry findings.MethodsParticipants included adults presenting for anorectal manometry for CC (N= 468, 82% female,Mage= 47). Depression/anxiety symptoms and eating disorder (ED) symptoms (EAT‐26) were used as indicators (i.e., variables used to derive profiles) representing unique psychological constructs. Constipation symptoms, GI‐specific anxiety, BMI, and anorectal manometry results were used as validators (i.e., variables used to examine the clinical utility of the resulting profiles).Key ResultsA 5‐profile solution provided the best statistical fit, comprising the following latent profiles (LPs): LP1 termed “high dieting, low bulimia;” LP2 termed “high ED symptoms;” LP3 termed “moderate ED symptoms;” LP4 termed “high anxiety and depression, low ED symptoms;” and LP5 termed “low psychological symptoms.” The low psychological symptom profile (61% of the sample) had lower abdominal and overall constipation severity and lower GI‐specific anxiety compared to the four profiles characterized by higher psychological symptoms (of any type). Profiles did not significantly differ on BMI or anorectal manometry results.Conclusions and InferencesProfiles with high psychological symptoms had increased constipation symptom severity and GI‐specific anxiety in adults with CC. Future research should test whether these profiles predict differential treatment outcomes.
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根据罗马 IV 标准，与功能性腹泻或功能性便秘相比，肠易激综合征患者的心理困扰和躯体化程度增加
影响因子：
3.5
作者：
Mohamed G. Shiha;Zohaib Asghar;M. Thoufeeq;M. Kurien;A. Ball;A. Rej;F. Tai;S. Afify;I. Aziz
通讯作者：
I. Aziz
影响因子：
2
作者：
Han, Claire J.;Pike, Ken;Heitkemper, Margaret M.
通讯作者：
Heitkemper, Margaret M.
使用潜在类别分析识别和验证功能性胃肠道疾病亚型：一项基于人群的研究
影响因子：
1.9
作者：
A. Zinsmeister;L. Herrick;Yuri A Saito Loftus;C. Schleck;N. Talley
通讯作者：
N. Talley
影响因子：
5.4
作者：
Zickgraf, Hana F.;Ellis, Jordan M.
通讯作者：
Ellis, Jordan M.
女性便秘型肠易激综合症的焦虑、抑郁和睡眠障碍
DOI：
--
发表时间：
2005
期刊：
影响因子：
--
作者：
S. Han;O. Lee;Y. Lee;Kwuybun Kim;B. Yoon;H. Choi
通讯作者：
H. Choi