Identification and validation of functional gastrointestinal disorder subtypes using latent class analysis: a population-based study
Identification and validation of functional gastrointestinal disorder subtypes using latent class analysis: a population-based study
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使用潜在类别分析识别和验证功能性胃肠道疾病亚型：一项基于人群的研究
DOI：
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发表时间：
2018
影响因子：
1.9
通讯作者：
N. Talley
中科院分区：
文献类型：
--
作者：
A. Zinsmeister;L. Herrick;Yuri A Saito Loftus;C. Schleck;N. Talley
目的：根据报告的症状对不同的功能性胃肠道疾病进行分类的尝试仍在继续，但症状经常重叠。研究目的是使用潜伏类分析（LCA），该分析可容纳连续和离散的显性变量，以确定基于人群的样本中使用胃肠道症状和患者数据的相互排斥的亚组分配。材料与方法：将一份有效的肠道疾病问卷和躯体症状问卷邮寄至按年龄和性别分层随机抽取的社区样本。根据罗马IV标准，对症状问题的回答分为频繁和不频繁。使用校准子集开发了LCA模型，并将结果应用于验证子集。结果：调查对象3831人（48%），资料完整者3425人。LCA算法对数据集的10个（随机）分裂中的每一个运行，并指定了2-6个潜在类。使用赤池信息标准系数c的值来确定数据的拟合，4个潜在类别产生了更好的值，从而产生4个亚组：“无症状”、“上”腹部症状、“下”腹部症状和“混合性”（上腹和下腹）。结论：潜在分类分析根据症状确定了4组。这种方法导致了解剖区域的分化，而不是症状的罗马IV分类。
Abstract Objective: Attempts to categorize distinct functional gastrointestinal disorders based on reported symptoms continue but symptoms frequently overlap. The study objective was to use latent class analysis (LCA) which accommodates both continuous and discrete manifest variables to determine mutually exclusive subgroup assignments of a population-based sample using gastrointestinal symptom and patient data. Materials and methods: A validated bowel disease questionnaire and somatic symptom questionnaire were mailed to an age and gender stratified randomly selected community sample. Responses to the symptom questions were dichotomized as frequent vs. infrequent based on Rome IV criteria. A LCA model was developed using a calibration subset and the results applied to the validation subset. Results: There were 3831 total respondents (48%) with 3425 having complete data. The LCA algorithm was run for each of 10 (random) splits of the dataset and 2–6 latent classes were specified. Using the values of Akaike’s Information Criterion coefficient c to determine fit of the data, 4 latent classes yielded better values resulting in four subgroups: ‘asymptomatic,’ ‘upper’ abdominal symptoms, ‘lower’ abdominal symptoms, and ‘mixed’ (upper and lower abdomen). Conclusions: Latent class analysis identified 4 groups based on symptoms. This approach resulted in differentiation by anatomical region rather than the Rome IV classification of symptoms.
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影响因子：
8.9
作者：
St Sauver, Jennifer L.;Grossardt, Brandon R.;Rocca, Walter A.
通讯作者：
Rocca, Walter A.
影响因子：
5
作者：
St Sauver, Jennifer L.;Grossardt, Brandon R.;Rocca, Walter A.
通讯作者：
Rocca, Walter A.
影响因子：
29.4
作者：
Halder, Smita L. S.;Locke, G. Richard, III;Talley, Nicholas J.
通讯作者：
Talley, Nicholas J.
美国和意大利人群肠道症状的因素分析。
DOI：
10.1016/s1590-8658(03)00456-0
发表时间：
2003
期刊：
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
影响因子：
--
作者：
Whitehead,WE;Bassotti,G;Palsson,O;Taub,E;Cook3rd,EC;Drossman,DA
通讯作者：
Drossman,DA