Linking inter-individual differences in the conflict adaptation effect to spontaneous brain activity
Linking inter-individual differences in the conflict adaptation effect to spontaneous brain activity
复制标题
将冲突适应效应的个体差异与自发大脑活动联系起来
DOI：
10.1016/j.neuroimage.2013.12.055
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发表时间：
2014-04
期刊：
影响因子：
5.7
通讯作者：
Chen, Antao
中科院分区：
文献类型：
--
作者：
Liu, Congcong;Zhao, Xiaoyue;Liu, Yijun;Chen, Antao
冲突适应在正常人群和临床人群中得到了广泛的研究。冲突适应存在很大的个体差异，并与分裂型特质有关。然而，到目前为止，还没有研究检验自发大脑活动的个体差异如何与行为冲突适应(表现)相关。静息功能磁共振成像(RS-fMRI)是研究这一问题的一种很有前途的工具。本研究评估了RS-fMRI信号的区域同质性(REHO)，以探讨冲突适应个体差异的神经基础。这两个独立样本共包括67名正常人。在控制反应时、标准差和侧翼干扰效应的情况下，进行偏相关分析以检验REHO与行为冲突适应的关系。对39名受试者的数据(样本1)进行了分析；结果显示，左侧背外侧前额叶皮质(DLPFC)和左侧腹外侧额叶皮质之间存在显著的正相关。然后，我们对其余28名受试者的数据(样本2)进行了测试-验证程序，以检查结果的可靠性。根据相关结果定义感兴趣区域。回归分析表明，DLPFC中REHO值的变异性可以解释样本2中冲突适应效应个体差异的48%。本研究结果进一步支持了DLPFC在冲突适应过程中的重要性。更重要的是，我们证明了DLPFC中RS-fMRI信号的REHO可以预测冲突适应中的行为表现，这为早期发现认知控制恶化提供了潜在的生物标志物。
Conflict adaptation has been widely researched in normal and clinical populations. There are large individual differences in conflict adaptation, and it has been linked to the schizotypal trait. However, no study to date has examined how individual differences in spontaneous brain activity are related to behavioral conflict adaptation (performance). Resting-state functional magnetic resonance imaging (RS-fMRI) is a promising tool to investigate this issue. The present study evaluated the regional homogeneity (ReHo) of RS-fMRI signals in order to explore the neural basis of individual differences in conflict adaptation across two independent samples comprising a total of 67 normal subjects. A partial correlation analysis was carried out to examine the relationship between ReHo and behavioral conflict adaptation, while controlling for reaction time, standard deviation and flanker interference effects. This analysis was conducted on 39 subjects' data (sample 1); the results showed significant positive correlations in the left dorsolateral prefrontal cortex (DLPFC) and left ventrolateral prefrontal cortex. We then conducted a test-validation procedure on the remaining 28 subjects' data (sample 2) to examine the reliability of the results. Regions of interest were defined based on the correlation results. Regression analysis showed that variability in ReHo values in the DLPFC accounted for 48% of the individual differences in the conflict adaptation effect in sample 2. The present findings provide further support for the importance of the DLPFC in the conflict adaptation process. More importantly, we demonstrated that ReHo of RS-fMRI signals in the DLPFC can predict behavioral performance in conflict adaptation, which provides potential biomarkers for the early detection of cognitive control deterioration.
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影响因子：
2.5
作者：
Leiqiong Wang;Ming Song;T. Jiang;Yunting Zhang;Chunshui Yu
通讯作者：
Leiqiong Wang;Ming Song;T. Jiang;Yunting Zhang;Chunshui Yu
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.1
作者：
GRATTON, G;COLES, MGH;DONCHIN, E
通讯作者：
DONCHIN, E
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
Tao Blockindeng
通讯作者：
Tao Blockindeng
影响因子：
5.4
作者：
M. Botvinick;T. Braver;D. Barch;C. Carter;J. Cohen
通讯作者：
M. Botvinick;T. Braver;D. Barch;C. Carter;J. Cohen