Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities.
Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities.
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DOI：
10.3390/cancers14102539
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发表时间：
2022-05-21
期刊：
影响因子：
5.2
通讯作者：
Chua, Boon H.
中科院分区：
文献类型：
--
作者：
Farr, Katherina P.;Moses, Daniel;Haghighi, Koroush S.;Phillips, Phoebe A.;Hillenbrand, Claudia M.;Chua, Boon H.
关键词：
虽然在过去的20年里，许多癌症的生存率有了显着提高，但胰腺癌患者的预后一直很差。大多数胰腺癌患者由于诊断时的局部晚期或转移性疾病阶段而不适合进行潜在的治愈性手术。因此，早期发现可能会通过早期干预改善胰腺癌患者的生存率。在这里，我们提出了胰腺癌早期检测的临床挑战，胰腺癌的高风险人群和目前的筛查计划在高风险个体。本综述的目的是探讨既有的影像学检查方法和新的影像学检查方法在胰腺癌早期诊断中的作用。此外，我们研究了用于胰腺癌早期检测的创新成像技术，但其广泛应用需要进一步研究，并可能与其他非侵入性生物标志物相结合。胰腺癌是最致命的恶性肿瘤之一，其发病率正在上升。虽然在过去的20年里，许多癌症的生存率都有了显著的提高，但胰腺癌患者的预后一直很差。胰腺癌的潜在治愈包括手术切除和辅助治疗。然而，大约85%的胰腺癌患者由于局部晚期或转移性疾病阶段而不适合潜在的治愈性治疗。由于这种鲜明的生存对比，早期发现的任何改善都可能通过早期干预显著改善胰腺癌患者的生存。这一全面的范围审查描述了目前关于胰腺癌高危人群的证据，包括具有遗传易感性、胰腺囊性病变、糖尿病和胰腺炎的个体。我们回顾了目前的作用，影像学方式的重点是胰腺癌的早期发现。此外，我们建议使用先进的成像方式来识别早期，潜在的可治愈的胰腺癌的高危人群。我们讨论了用于胰腺癌早期检测的创新成像技术，但其广泛应用需要进一步研究，并可能与其他非侵入性生物标志物相结合。
While survival rates for many cancers have improved dramatically over the last 20 years, patients with pancreatic cancer have persistently poor outcomes. The majority of patients with pancreatic cancer are not suitable for potentially curative surgery due to locally advanced or metastatic disease stage at diagnosis. Therefore, early detection would potentially improve survival of pancreatic cancer patients through earlier intervention. Here, we present clinical challenges in the early detection of pancreatic cancer, characterise high risk groups for pancreatic cancer and current screening programs in high-risk individuals. The aim of this scoping review is to investigate the role of both established and novel imaging modalities for early detection of pancreatic cancer. Furthermore, we investigate innovative imaging techniques for early detection of pancreatic cancer, but its widespread application requires further investigation and potentially a combination with other non-invasive biomarkers. Pancreatic cancer, one of the most lethal malignancies, is increasing in incidence. While survival rates for many cancers have improved dramatically over the last 20 years, people with pancreatic cancer have persistently poor outcomes. Potential cure for pancreatic cancer involves surgical resection and adjuvant therapy. However, approximately 85% of patients diagnosed with pancreatic cancer are not suitable for potentially curative therapy due to locally advanced or metastatic disease stage. Because of this stark survival contrast, any improvement in early detection would likely significantly improve survival of patients with pancreatic cancer through earlier intervention. This comprehensive scoping review describes the current evidence on groups at high risk for developing pancreatic cancer, including individuals with inherited predisposition, pancreatic cystic lesions, diabetes, and pancreatitis. We review the current roles of imaging modalities focusing on early detection of pancreatic cancer. Additionally, we propose the use of advanced imaging modalities to identify early, potentially curable pancreatic cancer in high-risk cohorts. We discuss innovative imaging techniques for early detection of pancreatic cancer, but its widespread application requires further investigation and potentially a combination with other non-invasive biomarkers.
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影响因子：
24.5
作者：
European Study Group on Cystic Tumours of the Pancreas
通讯作者：
European Study Group on Cystic Tumours of the Pancreas
影响因子：
7.7
作者：
Andersen DK;Korc M;Petersen GM;Eibl G;Li D;Rickels MR;Chari ST;Abbruzzese JL
通讯作者：
Abbruzzese JL
DOI：
10.3390/diagnostics10121042
发表时间：
2020-12-03
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Arnone A;Laudicella R;Caobelli F;Guglielmo P;Spallino M;Abenavoli E;Martini AL;Filice R;Comis AD;Cuzzocrea M;Linguanti F;Evangelista L;Alongi P
通讯作者：
Alongi P
DOI：
10.1097/ppo.0000000000000109
发表时间：
2015-05
期刊：
Cancer journal (Sudbury, Mass.)
影响因子：
--
作者：
Dimastromatteo J;Houghton JL;Lewis JS;Kelly KA
通讯作者：
Kelly KA
影响因子：
51.1
作者：
Arnold, Melina;Rutherford, Mark J.;Bray, Freddie
通讯作者：
Bray, Freddie