Perspective: Aggregation-induced emission as an emerging strategy for exploring pharmacokinetics of oral polysaccharides
Perspective: Aggregation-induced emission as an emerging strategy for exploring pharmacokinetics of oral polysaccharides
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观点：聚集诱导发射作为探索口服多糖药代动力学的新兴策略
DOI：
10.1080/07328303.2018.1430235
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发表时间：
2018-02
影响因子：
1
通讯作者：
Xiaoping Lai
中科院分区：
文献类型：
--
作者：
Qingping Xiong;Haojie Shi;Shijie Li;Yao Chen;Yonglin Zhao;Yi Jing;Jun Yuan;Xiaoping Lai
摘要多糖的临床应用受到各种悬而未决和有争议的药代动力学问题的严重限制。因此，迫切需要建立准确的多糖及其代谢物检测方法。聚集诱导发射(AIE)是螺旋桨形分子特有的光物理现象。目前，AIE已成功地实现了多糖凝胶过程的可视化，以及对阿霉素药物释放的时空准确监测。特别是，作者发现聚集事件总是发生在药代动力学过程中。因此，毛细管电泳法是一种很有前途的检测多糖类物质及其生物利用度的方法。图形摘要
ABSTRACT Clinical application of polysaccharides is severely limited by their various pending and controversial pharmacokinetics problems. Thus, it is urgent to develop accurate detection methods for polysaccharides and their metabolites. Aggregation-induced emission (AIE) is a unique photophysical phenomenon of propeller-shaped molecules. Currently, AIE has been successfully used to realize visualization for gelation process of polysaccharides, and accurate monitoring of spatiotemporal drug release of doxorubicin. In particular, authors found that aggregation event always happens during the pharmacokinetic process. Therefore, it is proposed that AIE can be a promising method for accurate detection of polysaccharides as well as elucidation of their bioavailability. GRAPHICAL ABSTRACT
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影响因子：
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