Electrophysiological measurement of the effect of inter-stimulus competition on early cortical stages of human vision.
Electrophysiological measurement of the effect of inter-stimulus competition on early cortical stages of human vision.
复制标题
DOI：
10.1016/j.neuroimage.2014.10.033
复制
发表时间：
2015-01-15
期刊：
影响因子：
5.7
通讯作者：
Luck SJ
中科院分区：
文献类型：
--
作者：
Miller CE;Shapiro KL;Luck SJ
通过几十年的动物单细胞和人类fMRI研究，早期视觉皮层输入之间的竞争已经被确定为感知的关键决定因素。我们开发了一种新的ERP范式，允许在人类中研究这种竞争，提供了一个机会，以进一步了解竞争如何在神经水平上反映。棋盘式刺激引出C1（V1中的索引处理），C2（假设在纹外反馈后反映V1）和P1（纹外）组件。刺激呈现在三种随机条件下：单刺激、近距离对和远距离对。重要的是，近刺激（相隔0.16°视角）被定位在初级视觉皮层中竞争，而远刺激（相隔2°）被定位在纹外视觉区中竞争。正如预测的那样，竞争的程度和空间范围增加，从C1组件到C2和P1组件。具体而言，竞争性的相互作用C1振幅是温和的，只存在于近距离对，而大量的竞争是存在的P1，即使是远距离对。据我们所知，这是第一项测量竞争如何随着时间的推移在人类视觉皮层中展开的研究。重要的是，这种方法提供了一种在视觉处理的特定阶段测量竞争相互作用的经验方法，从而可以严格测试竞争对感知，注意力和工作记忆的影响的预测。测量人类视觉皮层中竞争如何随时间推移而展开的新范式。竞争的程度和空间范围增加了第一个150毫秒poststimulus。近距离对的C1相互作用;即使在远距离也有大的P1相互作用。
Competition between inputs in early visual cortex has been established as a key determinant in perception through decades of animal single cell and human fMRI research. We developed a novel ERP paradigm allowing this competition to be studied in humans, affording an opportunity to gain further insight into how competition is reflected at the neural level. Checkerboard stimuli were presented to elicit C1 (indexing processing in V1), C2 (hypothesized to reflect V1 after extrastriate feedback), and P1 (extrastriate) components. Stimuli were presented in three randomized conditions: single stimulus, near proximity pairs and far proximity pairs. Importantly, near stimuli (0.16° visual angle apart) were positioned to compete in primary visual cortex, whereas far stimuli (2° apart) were positioned to compete in extrastriate visual areas. As predicted, the degree and spatial range of competition increased from the C1 component to the C2 and P1 components. Specifically, competitive interactions in C1 amplitude were modest and present only for near-proximity pairs, whereas substantial competition was present for the P1, even for far-proximity pairs. To our knowledge, this is the first study to measure how competition unfolds over time in human visual cortex. Importantly, this method provides an empirical means of measuring competitive interactions at specific stages of visual processing, rendering it possible to rigorously test predictions about the effects of competition on perception, attention, and working memory. Novel paradigm measuring how competition unfolds over time in human visual cortex. Degree and spatial range of competition increased over the first 150 ms poststimulus. C1 interactions for near-proximity pairs; large P1 interactions even at far-proximity.
登录
查看更多内容
影响因子：
5.7
作者：
Ales, Justin M.;Yates, Jacob L.;Norcia, Anthony M.
通讯作者：
Norcia, Anthony M.
影响因子：
6.6
作者：
Kappenman, Emily S.;Luck, Steven J.
通讯作者：
Luck, Steven J.
影响因子：
3.7
作者：
Kiesel, Andrea;Miller, Jeff;Brisson, Benoit
通讯作者：
Brisson, Benoit
影响因子：
--
作者：
FLOM, MC;KAHNEMAN, D;WEYMOUTH, FW
通讯作者：
WEYMOUTH, FW
影响因子：
3.8
作者：
ALPERN, M;DAVID, H
通讯作者：
DAVID, H