Mechanisms of myocardial regeneration.
Mechanisms of myocardial regeneration.
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DOI：
10.1016/j.tcm.2012.02.006
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发表时间：
2011-02
影响因子：
9.3
通讯作者：
Anversa, Piero
中科院分区：
文献类型：
--
作者：
Leri, Annarosa;Kajstura, Jan;Anversa, Piero
传统上，成人心脏被视为终末分化的有丝分裂后器官，其中心肌细胞的数量在出生时就已确定，并且这些细胞在器官和生物体的整个寿命期间持续存在。然而，心脏干细胞（CSCs）生活在心脏中并分化为各种心脏细胞谱系的发现极大地改变了我们对心肌生物学的理解。但是破译导致肌细胞更新的生物过程是一项具有挑战性的任务。心脏再生可以通过以下方式实现：1.在实质内产生所有特化谱系的多能干细胞的定型; 2.具有受限分化潜能的单能祖细胞的活化; 3.预先存在的分化细胞的复制; 4.经历可塑性转化的外源祖细胞转分化成不同于起源器官的细胞;和5.再进入细胞周期并分裂的心肌细胞的去分化。这些细胞生长的多种机制可以协同作用以再生复杂的结构并恢复靶器官的功能。
Traditionally, the adult heart has been viewed as a terminally differentiated post-mitotic organ in which the number of cardiomyocytes is established at birth and these cells persist throughout the lifespan of the organ and organism. However, the discovery that cardiac stem cells (CSCs) live in the heart and differentiate into the various cardiac cell lineages has dramatically changed our understanding of myocardial biology. But deciphering the biological processes that lead to myocyte renewal is a challenging task. Cardiac regeneration may be accomplished by: 1. commitment of multipotent stem cells that generate all specialized lineages within the parenchyma; 2. activation of unipotent progenitors with restricted differentiation potential; 3. replication of pre-existing differentiated cells; 4. transdifferentiation of exogenous progenitors that undergo plastic conversion into cells different from the organ of origin; and 5. dedifferentiation of cardiomyocytes that reenter the cell cycle and divide. These multiple mechanisms of cell growth may act in concert to regenerate complex structures and restore the function of the target organ.
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影响因子：
23.9
作者：
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通讯作者：
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影响因子：
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