Reciprocal influence of connexins and apical junction proteins on their expressions and functions.

Reciprocal influence of connexins and apical junction proteins on their expressions and functions.
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DOI:
10.1016/j.bbamem.2008.10.023
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发表时间:
2009-04
影响因子:
3.4
通讯作者:
Herve, Jean-Claude
Herve, Jean-Claude
中科院分区:
生物学3区
文献类型:
--
作者:
Derangeon, Mickael;Spray, David C.;Bourmeyster, Nicolas;Sarrouilhe, Denis;Herve, Jean-Claude

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相邻细胞的膜形成细胞间连接复合物,以机械地锚相邻细胞(锚定连接),密封细胞旁空间并防止完整蛋白质在质膜内扩散(紧密连接),并允许小离子和分子在细胞间扩散(间隙连接)。这些不同类型的专门质膜微区,共享共同的适配器分子,特别是闭锁小带蛋白,经常呈现混杂的关系,其中不同的蛋白质共组装成大分子复合物,并且它们的表达受到协调调节。形成间隙连接通道的蛋白质(特别是连接蛋白)和实现细胞附着或形成紧密连接链的蛋白质相互影响彼此的表达和功能。
Membranes of adjacent cells form intercellular junctional complexes to mechanically anchor neighbour cells (anchoring junctions), to seal the paracellular space and to prevent diffusion of integral proteins within the plasma membrane (tight junctions) and to allow cell-to-cell diffusion of small ions and molecules (gap junctions). These different types of specialised plasma membrane microdomains, sharing common adaptor molecules, particularly zonula occludens proteins, frequently present intermingled relationships where the different proteins co-assemble into macromolecular complexes and their expressions are co-ordinately regulated. Proteins forming gap junction channels (connexins, particularly) and proteins fulfilling cell attachment or forming tight junction strands mutually influence expression and functions of one another.
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