Mast cells and influenza a virus: association with allergic responses and beyond.
Mast cells and influenza a virus: association with allergic responses and beyond.
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DOI：
10.3389/fimmu.2015.00238
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发表时间：
2015
影响因子：
7.3
通讯作者：
Obar JJ
中科院分区：
文献类型：
--
作者：
Graham AC;Temple RM;Obar JJ
甲型流感病毒(IAV)是一种广泛存在于哺乳动物和禽类中的传染病。在人类中，IAV是一种呼吸道病原体，会导致季节性感染，在年轻人和老年人中有很高的发病率，并具有巨大的经济影响。此外，IAV有可能导致人畜共患外溢感染和全球大流行，这些疾病在所有年龄段的发病率和死亡率都要高得多。与这些大流行和外溢感染相关的病理似乎是过度的炎症反应导致严重的肺损伤，这可能使肺部容易发生继发性细菌感染。肺泡上皮细胞、内皮细胞、组织驻留的肺泡巨噬细胞、树突状细胞和肥大细胞保护肺免受病原体的侵袭。肥大细胞在细菌和寄生虫感染中的重要性已经被广泛研究；然而，这些造血细胞在病毒感染中的作用才刚刚开始显现。最近的研究表明，IAV可以直接激活肥大细胞，释放组胺、蛋白酶、白三烯、炎性细胞因子和抗病毒趋化因子等介质，参与IAV感染过程中的过度炎症和病理反应。在这篇综述中，我们将探讨肥大细胞与IAV之间的关系，并讨论肥大细胞在高度病理性IAV感染中作为潜在药物靶点的作用。最后，我们提出了肥大细胞在其他与重要宿主病理相关的病毒感染中的新角色。
Influenza A virus (IAV) is a widespread infectious agent commonly found in mammalian and avian species. In humans, IAV is a respiratory pathogen that causes seasonal infections associated with significant morbidity in young and elderly populations, and has a large economic impact. Moreover, IAV has the potential to cause both zoonotic spillover infection and global pandemics, which have significantly greater morbidity and mortality across all ages. The pathology associated with these pandemic and spillover infections appear to be the result of an excessive inflammatory response leading to severe lung damage, which likely predisposes the lungs for secondary bacterial infections. The lung is protected from pathogens by alveolar epithelial cells, endothelial cells, tissue resident alveolar macrophages, dendritic cells, and mast cells. The importance of mast cells during bacterial and parasitic infections has been extensively studied; yet, the role of these hematopoietic cells during viral infections is only beginning to emerge. Recently, it has been shown that mast cells can be directly activated in response to IAV, releasing mediators such histamine, proteases, leukotrienes, inflammatory cytokines, and antiviral chemokines, which participate in the excessive inflammatory and pathological response observed during IAV infections. In this review, we will examine the relationship between mast cells and IAV, and discuss the role of mast cells as a potential drug target during highly pathological IAV infections. Finally, we proposed an emerging role for mast cells in other viral infections associated with significant host pathology.
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影响因子：
4.4
作者：
Boonnak, Kobporn;Vogel, Leatrice;Subbarao, Kanta
通讯作者：
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DOI：
10.1038/nri2782
发表时间：
2010-06
期刊：
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影响因子：
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DOI：
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发表时间：
2010-06-04
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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