Totally Implantable Bidirectional Neural Prostheses: A Flexible Platform for Innovation in Neuromodulation.

Totally Implantable Bidirectional Neural Prostheses: A Flexible Platform for Innovation in Neuromodulation.
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DOI:
10.3389/fnins.2018.00619
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发表时间:
2018
影响因子:
4.3
通讯作者:
Starr PA
Starr PA
中科院分区:
医学2区
文献类型:
--
作者:
Starr PA

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植入式神经假体广泛用于治疗各种脑部疾病。直到最近,大多数植入式大脑设备都是单向的,要么在没有大脑传感的情况下传递神经刺激,要么在没有刺激组件的情况下传感大脑活动以驱动外部效应器。此外,许多包含传感功能的神经接口依赖于硬连线连接,使得受试者被束缚到外部计算机并且不能自由移动。新一代的神经假体已经出现,它们既可以双向(刺激和记录大脑活动),也可以完全植入(没有外部连接)。这些设备提供了一个机会,发现神经精神疾病的电路基础,并原型个性化的神经调节治疗,选择性地中断神经活动的具体迹象和症状。
Implantable neural prostheses are in widespread use for treating a variety of brain disorders. Until recently, most implantable brain devices have been unidirectional, either delivering neurostimulation without brain sensing, or sensing brain activity to drive external effectors without a stimulation component. Further, many neural interfaces that incorporate a sensing function have relied on hardwired connections, such that subjects are tethered to external computers and cannot move freely. A new generation of neural prostheses has become available, that are both bidirectional (stimulate as well as record brain activity) and totally implantable (no externalized connections). These devices provide an opportunity for discovering the circuit basis for neuropsychiatric disorders, and to prototype personalized neuromodulation therapies that selectively interrupt neural activity underlying specific signs and symptoms.
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