Brain network analysis reveals that amyloidopathy affects comorbid cognitive dysfunction in older adults with depression.
Brain network analysis reveals that amyloidopathy affects comorbid cognitive dysfunction in older adults with depression.
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DOI：
10.1038/s41598-021-83739-3
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发表时间：
2021-02-22
影响因子：
4.6
通讯作者：
Jeong HG
中科院分区：
文献类型：
--
作者：
Lee S;Kim D;Youn H;Hyung WSW;Suh S;Kaiser M;Han CE;Jeong HG
老年抑郁症（LLD）可能会增加阿尔茨海默氏痴呆症（AD）的风险。虽然淀粉样蛋白病加速AD进展，但其在此类患者中的作用尚未阐明。我们假设脑淀粉样病变明显影响脑网络拓扑结构的改变，并可能与不同的认知症状。我们分别招募了26名和27名伴有（LLD-MCI-A（+））和不伴有淀粉样蛋白积聚（LLD-MCI-A（-））的抑郁症轻度认知障碍（MCI）患者，以及21名正常对照。我们使用它们的扩散加权图像提取结构脑网络。我们的目的是比较有和没有淀粉样蛋白积累的LLD-MCI中的明显网络恶化以及与其明显认知下降的关系。因此，我们对网络拓扑测量进行了分组比较，并研究了与神经认知测试分数的任何相关性。脑网络的拓扑特征根据淀粉样蛋白积聚的存在而不同。在LLD-MCI-A（+）患者中，网络连接中断与回忆和识别受损高度相关。LLD-MCI-A（−）患者的注意力不集中和执行功能障碍更多地受到涉及额边缘电路功能障碍的网络改变的影响。我们的研究结果表明，大脑网络拓扑结构的改变可能反映了不同的认知功能障碍，这取决于淀粉样蛋白的积累在抑郁的老年人MCI。
Late-life depression (LLD) may increase the risk of Alzheimer’s dementia (AD). While amyloidopathy accelerates AD progression, its role in such patients has not yet been elucidated. We hypothesized that cerebral amyloidopathy distinctly affects the alteration of brain network topology and may be associated with distinct cognitive symptoms. We recruited 26 and 27 depressed mild cognitive impairment (MCI) patients with (LLD-MCI-A(+)) and without amyloid accumulation (LLD-MCI-A(−)), respectively, and 21 normal controls. We extracted structural brain networks using their diffusion-weighted images. We aimed to compare the distinct network deterioration in LLD-MCI with and without amyloid accumulation and the relationship with their distinct cognitive decline. Thus, we performed a group comparison of the network topological measures and investigated any correlations with neurocognitive testing scores. Topological features of brain networks were different according to the presence of amyloid accumulation. Disrupted network connectivity was highly associated with impaired recall and recognition in LLD-MCI-A(+) patients. Inattention and dysexecutive function were more influenced by the altered networks involved in fronto-limbic circuitry dysfunction in LLD-MCI-A(−) patients. Our results show that alterations in brain network topology may reflect different cognitive dysfunction depending on amyloid accumulation in depressed older adults with MCI.
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影响因子：
3.8
作者：
Brewer AA;Barton B
通讯作者：
Barton B
影响因子：
2.9
作者：
Bature F;Guinn BA;Pang D;Pappas Y
通讯作者：
Pappas Y
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
4.5
作者：
Ahn HJ;Chin J;Park A;Lee BH;Suh MK;Seo SW;Na DL
通讯作者：
Na DL
DOI：
10.1523/jneurosci.1521-08.2008
发表时间：
2008-10-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Clarke HF;Robbins TW;Roberts AC
通讯作者：
Roberts AC