Dynamic networks differentiate the language ability of children with cochlear implants.
Dynamic networks differentiate the language ability of children with cochlear implants.
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DOI：
10.3389/fnins.2023.1141886
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发表时间：
2023
影响因子：
4.3
通讯作者：
Gracco, Vincent L.
中科院分区：
文献类型：
--
作者：
Koirala, Nabin;Deroche, Mickael L. D.;Wolfe, Jace;Neumann, Sara;Bien, Alexander G.;Doan, Derek;Goldbeck, Michael;Muthuraman, Muthuraman;Gracco, Vincent L.
关键词：
语前聋儿童的人工耳蜗植入（CI）已被证明是发展语言和阅读技能的有效干预措施。然而，有相当一部分接受 CI 的孩子在语言和阅读方面存在困难。目前的研究是第一个在 CI 人群中实施电源成像的研究，旨在确定两组语言和阅读能力良好和较差的 CI 儿童的神经基础。在静息状态下使用高密度脑电图 (EEG) 获得的数据来自 75 名儿童，其中 50 名具有良好 (HL) 或较差语言能力 (LL) 的 CI 儿童和 25 名正常听力 (NH) 儿童。我们使用相干源动态成像 (DICS) 识别相干源，并根据时间部分定向相干性 (TPDC) 计算时频因果关系估计，在两个 CI 组中与年龄和性别匹配的 NH 儿童进行比较。与正常听力儿童相比，CI 组在三个频带（α、β 和 γ）中观察到具有更高相干幅度的源。两组具有良好（HL）和较差（LL）语言能力的CI儿童不仅表现出不同的皮质和皮质下源特征，而且它们之间也存在明显的有效连接。此外，支持向量机 (SVM) 算法使用这些源及其跨三个频段的每个 CI 组的连接模式，能够高精度预测语言和阅读分数。 CI 组中一致性的增加总体表明，与 NH 组相比，某些大脑区域的振荡活动变得更强耦合。此外，两组的不同来源及其连接模式及其与语言和阅读技能的关联表明，存在一种补偿性适应，促进或阻碍了语言和阅读的发展。两组 CI 儿童的神经差异可能反映了预测 CI 儿童结局成功的潜在生物标志物。
Cochlear implantation (CI) in prelingually deafened children has been shown to be an effective intervention for developing language and reading skill. However, there is a substantial proportion of the children receiving CI who struggle with language and reading. The current study–one of the first to implement electrical source imaging in CI population was designed to identify the neural underpinnings in two groups of CI children with good and poor language and reading skill. Data using high density electroencephalography (EEG) under a resting state condition was obtained from 75 children, 50 with CIs having good (HL) or poor language skills (LL) and 25 normal hearing (NH) children. We identified coherent sources using dynamic imaging of coherent sources (DICS) and their effective connectivity computing time-frequency causality estimation based on temporal partial directed coherence (TPDC) in the two CI groups compared to a cohort of age and gender matched NH children. Sources with higher coherence amplitude were observed in three frequency bands (alpha, beta and gamma) for the CI groups when compared to normal hearing children. The two groups of CI children with good (HL) and poor (LL) language ability exhibited not only different cortical and subcortical source profiles but also distinct effective connectivity between them. Additionally, a support vector machine (SVM) algorithm using these sources and their connectivity patterns for each CI group across the three frequency bands was able to predict the language and reading scores with high accuracy. Increased coherence in the CI groups suggest overall that the oscillatory activity in some brain areas become more strongly coupled compared to the NH group. Moreover, the different sources and their connectivity patterns and their association to language and reading skill in both groups, suggest a compensatory adaptation that either facilitated or impeded language and reading development. The neural differences in the two groups of CI children may reflect potential biomarkers for predicting outcome success in CI children.
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影响因子：
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作者：
Chang, David T.;Ko, Alvin B.;Megerian, Cliff A.
通讯作者：
Megerian, Cliff A.
影响因子：
3.7
作者：
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通讯作者：
Sharma, Anu
在人工耳蜗使用者中增加了跨模式功能连接性。
影响因子：
4.6
作者：
Chen LC;Puschmann S;Debener S
通讯作者：
Debener S
影响因子：
14.5
作者：
Doucet, M. E.;Bergeron, F.;Lepore, F.
通讯作者：
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影响因子：
4.7
作者：
Deroche，Mickael L. D.;Wolfe，Jace;Gracco，Vincent L.
通讯作者：
Gracco，Vincent L.