Worldwide inverse correlation between Bacille Calmette-Guérin (BCG) immunization and COVID-19 mortality.
Worldwide inverse correlation between Bacille Calmette-Guérin (BCG) immunization and COVID-19 mortality.
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DOI：
10.1007/s15010-020-01566-6
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发表时间：
2021-06
期刊：
影响因子：
7.5
通讯作者：
Li WX
中科院分区：
文献类型：
--
作者：
Li WX
2019冠状病毒病（COVID-19）大流行已经蔓延到世界各国，不同国家受到的影响不同。该研究旨在了解在国家层面造成COVID-19不同影响的因素。使用截至2020年8月1日的数据，使用多变量统计分析评估了世界所有国家和地区与其他9个人口和社会经济因素相关的COVID-19死亡和病例。研究中分析的因素包括一个国家的COVID-19总死亡人数和每百万人口的病例数、人均国内生产总值（GDP）、人口密度、每百万人口的病毒检测量、年龄中位数、政府应对严格程度指数、每千人口的医院床位数量、极端贫困率、卡介苗接种率和白喉-破伤风-百日咳(白喉-破伤风-百日咳（白喉-破伤风-百日咳）免疫率。研究表明，一个国家每百万人COVID-19死亡人数与该国卡介苗接种率（r = - 0.50, p = 5.3e-5）呈显著负相关，与该国人均GDP （r = 0.39, p = 7.4e-3）和年龄中位数（r = 0.30, p = 0.042）呈显著相关，而每百万人COVID-19病例与人均GDP和每千人口检测数显著相关。为了控制可能的年龄混杂效应，在与年龄相匹配的倾向得分中评估了相关性。在年龄中位数最高的前61个国家中，卡介苗接种率与COVID-19病例（r = - 0.30, p = 0.02）和死亡（r = - 0.42, p = 0.0007）呈显著负相关。这项研究为越来越多的证据支持卡介苗接种可能可以预防COVID-19死亡率的观点提供了帮助。在线版本包含补充材料，可在10.1007/s15010-020-01566-6获得。
The coronavirus disease 2019 (COVID-19) pandemic has spread to all countries in the world, and different countries have been impacted differently. The study aims to understand what factors contribute to different COVID-19 impacts at the country level. Multivariate statistical analyses were used to evaluate COVID-19 deaths and cases relative to nine other demographic and socioeconomic factors in all countries and regions of the world using data as of August 1, 2020. The factors analyzed in the study include a country’s total COVID-19 deaths and cases per million population, per capita gross domestic product (GDP), population density, virus tests per million population, median age, government response stringency index, hospital beds availability per thousand population, extreme poverty rate, Bacille Calmette–Guérin (BCG) vaccination rate, and diphtheria–tetanus–pertussis (DTP3) immunization rate. The study reveals that COVID-19 deaths per million population in a country most significantly correlates, inversely, with the country’s BCG vaccination rate (r = − 0.50, p = 5.3e-5), and also significantly correlates a country’s per capita GDP (r = 0.39, p = 7.4e-3) and median age (r = 0.30, p = 0.042), while COVID-19 cases per million population significantly correlate with per capita GDP and tests per thousand population. To control for possible confounding effects of age, the correlation was assessed in countries propensity score matched for age. The inverse correlation between BCG vaccination rates and COVID-19 case (r = − 0.30, p = 0.02) and death (r = − 0.42, p = 0.0007) remained significant among the top 61 countries with the highest median age. This study contributes to a growing body of evidence supporting the notion that BCG vaccination may be protective against COVID-19 mortality. The online version contains supplementary material available at 10.1007/s15010-020-01566-6.
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影响因子：
5.5
作者：
通讯作者：
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DOI：
10.1073/pnas.2008410117
发表时间：
2020-07-28
影响因子：
11.1
作者：
Escobar, Luis E.;Molina-Cruz, Alvaro;Barillas-Mury, Carolina
通讯作者：
Barillas-Mury, Carolina
影响因子：
13.6
作者：
Berg, Martha K.;Yu, Qinggang;Kitayama, Shinobu
通讯作者：
Kitayama, Shinobu
DOI：
10.1136/bmj.i5170
发表时间：
2016-10-13
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Higgins JP;Soares-Weiser K;López-López JA;Kakourou A;Chaplin K;Christensen H;Martin NK;Sterne JA;Reingold AL
通讯作者：
Reingold AL
影响因子：
13.8
作者：
Usher, Nicholas T.;Chang, Suyoung;Aronson, Naomi E.
通讯作者：
Aronson, Naomi E.