Comparative Analysis of Nucleic Acid-Binding Polymers as Potential Anti-Inflammatory Nanocarriers.
Comparative Analysis of Nucleic Acid-Binding Polymers as Potential Anti-Inflammatory Nanocarriers.
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DOI：
10.3390/pharmaceutics16010010
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发表时间：
2023-12-20
期刊：
影响因子：
5.4
通讯作者：
Leong KW
中科院分区：
文献类型：
--
作者：
Bhansali D;Akinade T;Li T;Zhong Y;Liu F;Huang H;Tu Z;Devey EA;Zhu Y;Jensen DD;Leong KW
常规地，纳米载体用于调节治疗有效载荷的受控释放。它们也越来越多地被设计成具有内在的治疗效果。例如，带正电荷的纳米载体可以结合损伤相关的分子模式，抑制toll样受体（TLR）途径活化，从而调节炎症。这些核酸结合纳米材料（NABN），其抑制促炎刺激，以多种形式存在，从可溶性聚合物到纳米颗粒和2D纳米片。与主要解决炎症症状的传统药物不同，这些NABP通过去除引起炎症的激动剂来靶向上游炎症引发途径。许多NABN已在炎性疾病的鼠模型中证明有效。然而，这些清道夫还没有系统地研究和比较在一个单一的设置。在此，我们筛选了一组最有效的NABN，以确定它们在清除无细胞核酸和抑制各种TLR途径方面的相对效率。这项研究有助于解释现有的体内结果，并为抗炎纳米载体的未来设计提供见解。
Conventionally, nanocarriers are used to regulate the controlled release of therapeutic payloads. Increasingly, they can also be designed to have an intrinsic therapeutic effect. For example, a positively charged nanocarrier can bind damage-associated molecular patterns, inhibiting toll-like receptor (TLR) pathway activation and thus modulating inflammation. These nucleic acid-binding nanomaterials (NABNs), which scavenge pro-inflammatory stimuli, exist in diverse forms, ranging from soluble polymers to nanoparticles and 2D nanosheets. Unlike conventional drugs that primarily address inflammation symptoms, these NABPs target the upstream inflammation initiation pathway by removing the agonists responsible for inflammation. Many NABNs have demonstrated effectiveness in murine models of inflammatory diseases. However, these scavengers have not been systematically studied and compared within a single setting. Herein, we screen a subset of the most potent NABNs to define their relative efficiency in scavenging cell-free nucleic acids and inhibiting various TLR pathways. This study helps interpret existing in vivo results and provides insights into the future design of anti-inflammatory nanocarriers.
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DOI：
10.1007/s12291-022-01082-4
发表时间：
2023-04
期刊：
Indian journal of clinical biochemistry : IJCB
影响因子：
--
作者：
通讯作者：
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影响因子：
15.1
作者：
Li, Tianyu;Akinade, Tolulope;Zhou, Jie;Wang, Hongxia;Tong, Qisong;He, Siyu;Rinebold, Emily;Salazar, Luis E. Valencia;Bhansali, Divya;Zhong, Yiling;Ruan, Jing;Du, Jinzhi;Dalerba, Piero;Leong, Kam W.
通讯作者：
Leong, Kam W.
影响因子：
7.4
作者：
Fernandez-Garcia, Daniel;Hills, Allison;Shaw, Jacqueline A.
通讯作者：
Shaw, Jacqueline A.
影响因子：
32.4
作者：
Paludan SR;Bowie AG
通讯作者：
Bowie AG
纳米颗粒无细胞 DNA 清除剂用于治疗牙周炎炎症性骨质流失
影响因子：
16.6
作者：
Huang, Hanyao;Pan, Weiyi;Wang, Yifan;Kim, Hye Sung;Shao, Dan;Huang, Baoding;Ho, Tzu-Chieh;Lao, Yeh-Hsing;Quek, Chai Hoon;Shi, Jiayu;Chen, Qianming;Shi, Bing;Zhang, Shengmin;Zhao, Lei;Leong, Kam W.
通讯作者：
Leong, Kam W.