Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females.
Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females.
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DOI：
10.1016/j.neurobiolaging.2021.04.003
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发表时间：
2021-09
影响因子：
4.2
通讯作者：
Rabinovici GD
中科院分区：
文献类型：
--
作者：
Edwards L;La Joie R;Iaccarino L;Strom A;Baker SL;Casaletto KB;Cobigo Y;Grant H;Kim M;Kramer JH;Mellinger TJ;Pham J;Possin KL;Rosen HJ;Soleimani-Meigooni DN;Wolf A;Miller BL;Rabinovici GD
我们评估了119例轻度认知障碍或阿尔茨海默病（AD）痴呆的淀粉样蛋白阳性患者的淀粉样蛋白和tau-PET保留的性别差异。患者接受了3 T-MRI、11 C-PIB淀粉样蛋白-PET和18F-Flortaucipir tau-PET。线性普通最小二乘回归模型在感兴趣的汇总时间区域以及全局PIB-PET中检测了Flortaucipir-PET SUVR的性别差异。在人口统计学、临床痴呆评分总和（CDR-SoB）、简易精神状态检查（MMSE）、原始情景记忆评分或皮质厚度方面未观察到性别差异。女性的总体PIB SUVR（ηp2= 0.043，p= 0.025）和时间Flortaucipir SUVR（ηp2= 0.070，p= 0.004）较高，根据年龄和CDR-SoB进行调整。当额外控制PIB SUVR和APOE 4状态（ηp2= 0.055，p= 0.013）或使用部分体积校正数据时，时间Flortaucipir-PET的性别差异仍然显著。在已知的Flortaucipir脱靶结合区域中不存在性别差异。总体而言，尽管具有临床可比性，但女性的AD区域tau-PET负荷高于男性。性别差异的进一步表征将提供对AD发病机制的深入了解，并支持个性化治疗策略的发展。
We assessed sex differences in amyloid- and tau-PET retention in 119 amyloid positive patients with mild cognitive impairment or Alzheimer’s disease (AD) dementia. Patients underwent 3T-MRI, 11C-PIB amyloid-PET and 18F-Flortaucipir tau-PET. Linear ordinary least squares regression models tested sex differences in Flortaucipir-PET SUVR in a summary temporal region of interest as well as global PIB-PET. No sex differences were observed in demographics, Clinical Dementia Rating Sum of Boxes (CDR-SoB), Mini-Mental State Exam (MMSE), raw episodic memory scores, or cortical thickness. Females had higher global PIB SUVR (ηp2=.043, p=.025) and temporal Flortaucipir SUVR (ηp2=.070, p=.004), adjusting for age and CDR-SoB. Sex differences in temporal Flortaucipir-PET remained significant when controlling additionally for PIB SUVR and APOE4 status (ηp2=.055, p=.013), or when using partial volume-corrected data. No sex differences were present in areas of known Flortaucipir off-target binding. Overall, females demonstrated greater AD regional tau-PET burden than males despite clinical comparability. Further characterization of sex differences will provide insight into AD pathogenesis and support development of personalized therapeutic strategies.
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影响因子：
4.2
作者：
Armstrong, Nicole M.;Huang, Chiung-Wei;Resnick, Susan M.
通讯作者：
Resnick, Susan M.
影响因子：
14
作者：
通讯作者：
--
DOI：
10.1016/j.jalz.2013.10.005
发表时间：
2015-03
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Chêne G;Beiser A;Au R;Preis SR;Wolf PA;Dufouil C;Seshadri S
通讯作者：
Seshadri S
影响因子：
9.9
作者：
ARRIAGADA, PV;GROWDON, JH;HYMAN, BT
通讯作者：
HYMAN, BT
影响因子：
1.5
作者：
Bolla-Wilson, Karen;Bleecker, Margit L.
通讯作者：
Bleecker, Margit L.