Tumour Necrosis Factor-α Gene Polymorphism Is Associated with Metastasis in Patients with Triple Negative Breast Cancer.
Tumour Necrosis Factor-α Gene Polymorphism Is Associated with Metastasis in Patients with Triple Negative Breast Cancer.
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DOI：
10.1038/srep10244
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发表时间：
2015-07-13
影响因子：
4.6
通讯作者：
Zhai K
中科院分区：
文献类型：
--
作者：
Li HH;Zhu H;Liu LS;Huang Y;Guo J;Li J;Sun XP;Chang CX;Wang ZH;Zhai K
肿瘤坏死因子-α（TNF-α）在炎症和肿瘤进展的调节中至关重要。TNF-α-308 G> A与组成性升高的TNF-α表达相关。本研究的目的是评估TNF-α-308 G> A与乳腺癌（BC）亚型风险之间的关系，以及基因型与BC临床特征之间的联系。共纳入768例患者和565例对照，并使用TaqMan检测基因型。在我们的研究或汇总荟萃分析中，未发现TNF-α-308多态性对任何BC亚型的易感性有影响。这种多态性被证明与初潮年龄在所有BC和孕激素受体阴性BC。有趣的是，TNF-α-308A的三阴性乳腺癌（TNBC）患者的肿瘤远处转移风险增加（OR = 3.80，95%CI：1.31-11.02，P = 0.009）。多因素回归分析显示，在调整肿瘤大小和淋巴结转移情况后，TNF-α-308A也是肿瘤远处转移的危险因素（OR = 6.26，95%CI：1.88-20.87，P = 0.003）。这些结果表明TNF-α可能在TNBC的进展中发挥独特的作用，特别是在TNBC的远处肿瘤转移中。
Tumour necrosis factor-α (TNF-α) is critical in the regulation of inflammation and tumour progression. TNF-α-308G > A is associated with constitutively elevated TNF-α expression. The purpose of this study was to assess the association between TNF-α-308G > A and breast cancer (BC) risk by subtype and the connection between genotypes and clinical features of BC. A total of 768 patients and 565 controls were enrolled in this study, and genotypes were detected using the TaqMan assay. No effect on susceptibility for any BC subtype was found for the TNF-α-308 polymorphism in our study or in the pooled meta-analysis. This polymorphism was shown to be associated with age at menarche in all BC and in progesterone receptor-negative BC. Interestingly, triple negative breast cancer (TNBC) patients with TNF-α-308A had an increased risk of distant tumour metastasis (OR = 3.80, 95% CI: 1.31–11.02, P = 0.009). Multi-regression analysis showed that TNF-α-308A was also a risk factor for distant tumour metastasis after adjustment for tumour size and lymph node metastasis status (OR = 6.26, 95% CI: 1.88–20.87, P = 0.003). These findings indicate that TNF-α might play a distinct role in the progression of TNBC, especially in distant tumour metastasis of TNBC.
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作者：
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通讯作者：
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影响因子：
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作者：
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