Clinical identification of the stimulus intensity to measure temporal summation of second pain.
Clinical identification of the stimulus intensity to measure temporal summation of second pain.
复制标题
刺激强度的临床鉴定，以测量第二疼痛的时间求和。
DOI：
10.1038/s41598-022-17171-6
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发表时间：
2022-07-28
影响因子：
4.6
通讯作者：
Hirofumi, Yatani
中科院分区：
文献类型：
--
作者：
Daisuke, Moriguchi;Shoichi, Ishigaki;Xiaoyu, Lin;Kotaro, Kuyama;Yukiko, Koishi;Ryota, Takaoka;Peter, Svensson;Hirofumi, Yatani
第二痛的时间总和（TSSP）已被建议作为中枢敏感化的心理物理指标，中枢敏感化是疼痛慢性化的关键机制之一。然而，对于测量TSSP的协议没有金标准。目的是建立测量TSSP的刺激强度。慢性颞下颌关节肌筋膜疾病疼痛女性患者（n = 16）和无疼痛的健康女性志愿者（n = 15）参加了研究。测量疼痛阈值（PT °C），并施加三种刺激强度（PT °C、PT + 1 °C、PT + 2 °C）的重复热刺激。TSSP参数量化为TSSP幅度（TSm）和TSSP频率（TSf）。在健康女性志愿者中，PT °C下疼痛评分显著降低（p < 0.050），PT + 2 °C下的TSm和TSf显著高于PT °C下的TSm和TSf（p < 0.025）。在慢性疼痛患者中，在PT + 1 °C和PT + 2 °C下疼痛评级显著增加（p < 0.050）。在PT + 2 °C时，慢性疼痛患者的TSm和TSf显著高于健康志愿者（p < 0.050）。将刺激强度单独调整为患者的疼痛阈值+ 2 °C，测量TSSP可能有助于评估中枢致敏。
Temporal summation of second pain (TSSP) has been suggested as a psychophysical index for central sensitization, one of the critical mechanisms in the chronification of pain. However, there is no gold standard for protocols to measure TSSP. The purpose was to establish the stimulus intensity for measuring TSSP. Female patients with chronic myofascial temporomandibular disorders pain (n = 16) and healthy female volunteers with no pain (n = 15) participated. Pain thresholds (PT °C) were measured, and repetitive heat stimuli at three stimulus intensities (PT °C, PT + 1 °C, PT + 2 °C) were applied. TSSP parameters were quantified as TSSP magnitude (TSm) and TSSP frequency (TSf). In healthy female volunteers, pain ratings significantly decreased at PT °C (p < 0.050), besides TSm and TSf at PT + 2 °C were significantly higher than those at PT °C (p < 0.025). In chronic pain patients, pain ratings significantly increased at PT + 1 °C and PT + 2 °C (p < 0.050). At PT + 2 °C, TSm and TSf in chronic pain patients were significantly higher than those in healthy volunteers (p < 0.050). It could be helpful to measure TSSP with the stimulus intensity adjusted individually to the patient’s pain thresholds + 2 °C for assessing central sensitization.
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