Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome.
Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome.
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DOI：
10.1017/s0033291723001940
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发表时间：
2023-12
影响因子：
6.9
通讯作者：
Sukhodolsky, Denis G.
中科院分区：
文献类型：
--
作者：
Morand-Beaulieu, Simon;Crowley, Michael J.;Grantz, Heidi;Leckman, James F.;Sukhodolsky, Denis G.
抽搐综合行为干预（CBIT）被推荐作为儿童和成人抽动秽语综合征的一线治疗方法。虽然有强有力的证据证明其有效性，但在CBIT期间减少抽搐严重程度的机制仍然知之甚少。在最近的一项研究中，我们的研究小组发现了一个参与TS儿童抽动抑制的功能性脑网络。我们认为自愿抽动抑制和CBIT可能有一些共同的机制，因此我们想评估抽动抑制期间的功能连接是否与CBIT结果相关。32名年龄在8至13岁的TS儿童参加了CBIT与常规治疗对照条件的随机对照试验。所有参与者在基线和终点均记录抽搐抑制期间的脑电图。我们使用源重构的脑电图连接管道来评估抽搐抑制期间的功能连接。tic抑制期间的功能连通性从基线到终点没有变化。然而，基线抽动抑制相关的功能连通性特别预测了CBIT组从基线到终点的声带抽动严重程度的降低。补充分析表明，右额上回和右角回之间的功能连接是导致这种效果的主要原因。这项研究显示，抽动抑制期间的功能连通性在基线预测声带抽动严重程度的降低。这些结果表明自主抽动抑制机制和抽动行为治疗机制之间可能存在重叠。
Comprehensive Behavioral Intervention for Tics (CBIT) is recommended as a first-line treatment for Tourette syndrome in children and adults. While there is strong evidence proving its efficacy, the mechanisms of reduction in tic severity during CBIT are still poorly understood. In a recent study, our group identified a functional brain network involved in tic suppression in children with TS. We reasoned that voluntary tic suppression and CBIT may share some mechanisms and thus we wanted to assess whether functional connectivity during tic suppression was associated with CBIT outcome. Thirty-two children with TS, aged 8 to 13 years old, participated in a randomized controlled trial of CBIT v. a treatment-as-usual control condition. EEG was recorded during tic suppression in all participants at baseline and endpoint. We used a source-reconstructed EEG connectivity pipeline to assess functional connectivity during tic suppression. Functional connectivity during tic suppression did not change from baseline to endpoint. However, baseline tic suppression-related functional connectivity specifically predicted the decrease in vocal tic severity from baseline to endpoint in the CBIT group. Supplementary analyses revealed that the functional connectivity between the right superior frontal gyrus and the right angular gyrus was mainly driving this effect. This study revealed that functional connectivity during tic suppression at baseline predicted reduction in vocal tic severity. These results suggest probable overlap between the mechanisms of voluntary tic suppression and those of behavior therapy for tics.
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影响因子：
2
作者：
Ueda K;Kim S;Greene DJ;Black KJ
通讯作者：
Black KJ
DOI：
10.1016/j.bpsc.2021.05.001
发表时间：
2023-03
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
--
作者：
Morand-Beaulieu S;Wu J;Mayes LC;Grantz H;Leckman JF;Crowley MJ;Sukhodolsky DG
通讯作者：
Sukhodolsky DG
影响因子：
3.8
作者：
Shou S;Li Y;Fan G;Zhang Q;Yan Y;Lv T;Wang J
通讯作者：
Wang J
影响因子：
7.6
作者：
McGuire, Joseph F.;Sturm, Alexandra;Ricketts, Emily J.;Montalbano, Gabrielle E.;Chang, Susanna;Loo, Sandra K.;Woods, Douglas W.;McCracken, James;Piacentini, John
通讯作者：
Piacentini, John