Increased Alpha-Band Connectivity During Tic Suppression in Children With Tourette Syndrome Revealed by Source Electroencephalography Analyses.
Increased Alpha-Band Connectivity During Tic Suppression in Children With Tourette Syndrome Revealed by Source Electroencephalography Analyses.
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DOI：
10.1016/j.bpsc.2021.05.001
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发表时间：
2023-03
期刊：
影响因子：
--
通讯作者：
Sukhodolsky DG
中科院分区：
文献类型：
--
作者：
Morand-Beaulieu S;Wu J;Mayes LC;Grantz H;Leckman JF;Crowley MJ;Sukhodolsky DG
抽动秽语综合征（TS）是一种神经发育障碍性疾病，涉及慢性运动和语音抽动。大多数患有抽动秽语综合征的人至少可以在短时间内抑制抽搐。然而，抽动抑制的大脑相关性仍然知之甚少。在目前的研究中，高密度脑电图（EEG）记录在休息状态和抽搐抑制会议在72名儿童与TS。使用EEG源连接方法在α频带（8-13 Hz）中评估皮质区域之间的功能连接。使用图论和基于网络的统计来评估全局网络拓扑结构，并识别在抽动抑制期间显示连接性增加的大脑区域。图形理论分析显示，独特的全球网络拓扑结构在抽搐抑制，相对于休息。使用基于网络的统计数据，我们发现了一个在抽搐抑制期间连接性增加的子网络（p < .001）。该子网络包含许多皮层区域，包括右侧上级额回和左侧楔前叶，它们都参与了默认模式网络。我们还发现了一个条件，年龄的相互作用，表明年龄介导的增加连接在抽搐抑制。这些结果表明，患有TS的儿童通过涉及分布式皮层区域的大脑回路来抑制抽搐，其中许多是默认模式网络的一部分。随着青少年TS的成熟，抽动抑制过程中的大脑连接也会增加。这些结果强调了一种机制，通过这种机制，TS儿童可以控制他们的抽搐，这可能是相关的未来的治疗研究。
Tourette syndrome (TS) is a neurodevelopmental disorder involving chronic motor and phonic tics. Most individuals with Tourette syndrome can suppress their tics for at least a short period of time. Yet, the brain correlates of tic suppression are still poorly understood. In the current study, high-density electroencephalography (EEG) was recorded during a resting-state and a tic suppression session in 72 children with TS. Functional connectivity between cortical regions was assessed in the alpha band (8-13 Hz) using an EEG source connectivity method. Graph theory and network-based statistics were used to assess the global network topology and to identify brain regions showing increased connectivity during tic suppression. Graph theoretical analyses revealed distinctive global network topology during tic suppression, relative to rest. Using network-based statistics, we found a subnetwork of increased connectivity during tic suppression (p < .001). That subnetwork encompassed many cortical areas, including the right superior frontal gyrus and the left precuneus, which are involved in the default mode network. We also found a condition by age interaction, suggesting age-mediated increases in connectivity during tic suppression. These results suggest that children with TS suppress their tics through a brain circuit involving distributed cortical regions, many of which are part of the default mode network. Brain connectivity during tic suppression also increases as youths with TS mature. These results highlight a mechanism by which children with TS may control their tics, which could be relevant for future treatment studies.
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