Myeloid-derived suppressor cells: linking inflammation and cancer.
Myeloid-derived suppressor cells: linking inflammation and cancer.
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髓样衍生的抑制细胞：连接炎症和癌症。
DOI：
10.4049/jimmunol.0802740
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发表时间：
2009-04-15
期刊：
影响因子：
--
通讯作者：
Sinha P
中科院分区：
文献类型：
--
作者：
Ostrand-Rosenberg S;Sinha P
许多在实验动物身上开发的癌症免疫疗法已经在临床试验中得到了检验。虽然其中一些显示出适度的临床效果，但大多数没有效果。最近的研究发现，骨髓源性细胞是肿瘤免疫的有效抑制因子，因此是癌症免疫治疗的重大障碍。“髓源性抑制细胞”（MDSC）在大多数癌症患者和实验动物的血液、淋巴结、骨髓和肿瘤部位积聚，并抑制适应性和先天免疫。MDSC是由肿瘤分泌因子和宿主分泌因子诱导的，其中许多是促炎分子。促炎介质对MDSC的诱导导致了一种假设，即炎症促进MDSC的积累，从而下调免疫监视和抗肿瘤免疫，从而促进肿瘤生长。本文综述了MDSC阻断肿瘤免疫的特性和抑制机制，并描述了炎症通过诱导MDSC促进肿瘤进展的机制。
Many cancer immunotherapies developed in experimental animals have been tested in clinical trials. Although some have shown modest clinical effects, most have not been effective. Recent studies have identified myeloid-origin cells that are potent suppressors of tumor immunity and therefore a significant impediment to cancer immunotherapy. “Myeloid-derived suppressor cells” (MDSC) accumulate in the blood, lymph nodes, and bone marrow and at tumor sites in most patients and experimental animals with cancer and inhibit both adaptive and innate immunity. MDSC are induced by tumor-secreted and host-secreted factors, many of which are proinflammatory molecules. The induction of MDSC by proinflammatory mediators led to the hypothesis that inflammation promotes the accumulation of MDSC that down-regulate immune surveillance and antitumor immunity, thereby facilitating tumor growth. This article reviews the characterization and suppressive mechanisms used by MDSC to block tumor immunity and describes the mechanisms by which inflammation promotes tumor progression through the induction of MDSC.
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影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
DOI：
10.1084/jem.20080132
发表时间：
2008-09-29
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cheng P;Corzo CA;Luetteke N;Yu B;Nagaraj S;Bui MM;Ortiz M;Nacken W;Sorg C;Vogl T;Roth J;Gabrilovich DI
通讯作者：
Gabrilovich DI
影响因子：
11.2
作者：
Bunt, Stephanie K.;Yang, Linglin;Ostrand-Rosenberg, Suzanne
通讯作者：
Ostrand-Rosenberg, Suzanne
影响因子：
4.4
作者：
Bronte, V;Serafini, P;Zanovello, P
通讯作者：
Zanovello, P
DOI：
10.1084/jem.20062602
发表时间：
2007-06-11
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Delano MJ;Scumpia PO;Weinstein JS;Coco D;Nagaraj S;Kelly-Scumpia KM;O'Malley KA;Wynn JL;Antonenko S;Al-Quran SZ;Swan R;Chung CS;Atkinson MA;Ramphal R;Gabrilovich DI;Reeves WH;Ayala A;Phillips J;Laface D;Heyworth PG;Clare-Salzler M;Moldawer LL
通讯作者：
Moldawer LL