Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: what should be the policy?
Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: what should be the policy?
复制标题
DOI：
10.1016/j.neuroimage.2010.01.105
复制
发表时间：
2011-01
期刊：
影响因子：
5.7
通讯作者：
Heiss, John D.
中科院分区：
文献类型：
--
作者：
Kateb, Babak;Chiu, Katherine;Black, Keith L.;Yamamoto, Vicky;Khalsa, Bhavraj;Ljubimova, Julia Y.;Ding, Hui;Patil, Rameshwar;Portilla-Arias, Jose Antonio;Modo, Mike;Moore, David F.;Farahani, Keyvan;Okun, Michael S.;Prakash, Neal;Neman, Josh;Ahdoot, Daniel;Grundfest, Warren;Nikzad, Shouleh;Heiss, John D.
关键词：
纳米技术是设计和组装称为纳米颗粒的亚微观装置，直径为1-100纳米。纳米医学是应用纳米技术诊断和治疗人类疾病。细胞表面的疾病特异性受体为纳米颗粒提供了有用的靶点。由于纳米颗粒可以从（1）在细胞水平上识别疾病，（2）在成像研究中可见，以及（3）提供治疗化合物的成分中进行工程改造，因此纳米技术非常适合于各种疾病的诊断和治疗。纳米技术将能够更早地发现和治疗那些在最初阶段治疗效果最好的疾病，如癌症。纳米技术的进步也将刺激发现新的方法，将治疗化合物，包括基因和蛋白质，输送到患病组织。通过结合多种选择的靶向、诊断和治疗成分，可以开发出无数具有有效位点靶向的纳米结构药物。用纳米结构增强免疫靶点特异性为癌症患者引入了一种新型的治疗方式，纳米免疫化疗。在本文中，我们将讨论纳米平台在医学诊断和治疗中的发展和潜在应用。为了影响神经系统疾病患者的护理，纳米技术的进步将需要加速翻译到脑映射，CNS成像和纳米神经外科领域。纳米平台、纳米成像和纳米药物输送的进展将推动纳米医学、个性化医学和靶向治疗的未来发展。我们相信，科学，技术，医药法律医疗保健政策（STML）枢纽/中心，鼓励大学，医疗中心，美国政府，行业，患者倡导团体，慈善基金会和慈善家之间的合作，可以显着促进这种进步，并有助于跨医学学科的纳米技术的翻译。
Nanotechnology is the design and assembly of submicroscopic devices called nanoparticles, which are 1–100 nm in diameter. Nanomedicine is the application of nanotechnology for the diagnosis and treatment of human disease. Disease-specific receptors on the surface of cells provide useful targets for nanoparticles. Because nanoparticles can be engineered from components that (1) recognize disease at the cellular level, (2) are visible on imaging studies, and (3) deliver therapeutic compounds, nanotechnology is well suited for the diagnosis and treatment of a variety of diseases. Nanotechnology will enable earlier detection and treatment of diseases that are best treated in their initial stages, such as cancer. Advances in nanotechnology will also spur the discovery of new methods for delivery of therapeutic compounds, including genes and proteins, to diseased tissue. A myriad of nanostructured drugs with effective site-targeting can be developed by combining a diverse selection of targeting, diagnostic, and therapeutic components. Incorporating immune target specificity with nanostructures introduces a new type of treatment modality, nano-immunochemotherapy, for patients with cancer. In this review, we will discuss the development and potential applications of nanoscale platforms in medical diagnosis and treatment. To impact the care of patients with neurological diseases, advances in nanotechnology will require accelerated translation to the fields of brain mapping, CNS imaging, and nanoneurosurgery. Advances in nanoplatform, nano-imaging, and nano-drug delivery will drive the future development of nanomedicine, personalized medicine, and targeted therapy. We believe that the formation of a science, technology, medicine law–healthcare policy (STML) hub/center, which encourages collaboration among universities, medical centers, US government, industry, patient advocacy groups, charitable foundations, and philanthropists, could significantly facilitate such advancements and contribute to the translation of nanotechnology across medical disciplines.
登录
查看更多内容
影响因子：
4.9
作者：
Bianco, A;Kostarelos, K;Prato, M
通讯作者：
Prato, M
影响因子：
4.9
作者：
Amsharov, Konstantin;Jansen, Martin
通讯作者：
Jansen, Martin
影响因子：
5.7
作者：
Battah, Sinan;Balaratnam, Sherina;MacRobert, Alexander J.
通讯作者：
MacRobert, Alexander J.
影响因子：
4.7
作者：
Ballou, Byron;Ernst, Lauren A.;Bruchez, Marcel P.
通讯作者：
Bruchez, Marcel P.
影响因子：
20.3
作者：
Arbab, AS;Yocum, GT;Frank, JA
通讯作者：
Frank, JA