The role of astrocyte structural plasticity in regulating neural circuit function and behavior.
The role of astrocyte structural plasticity in regulating neural circuit function and behavior.
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作者：
Brain circuits undergo substantial structural changes during development, driven by the formation, stabilization, and elimination of synapses. Synaptic connections continue to undergo experience‐dependent structural rearrangements throughout life, which are postulated to underlie learning and memory. Astrocytes, a major glial cell type in the brain, are physically in contact with synaptic circuits through their structural ensheathment of synapses. Astrocytes strongly contribute to the remodeling of synaptic structures in healthy and diseased central nervous systems by regulating synaptic connectivity and behaviors. However, whether structural plasticity of astrocytes is involved in their critical functions at the synapse is unknown. This review will discuss the emerging evidence linking astrocytic structural plasticity to synaptic circuit remodeling and regulation of behaviors. Moreover, we will survey possible molecular and cellular mechanisms regulating the structural plasticity of astrocytes and their non‐cell‐autonomous effects on neuronal plasticity. Finally, we will discuss how astrocyte morphological changes in different physiological states and disease conditions contribute to neuronal circuit function and dysfunction. Astrocytes are highly complex cells which display structural plasticity. Here we review recent findings linking astrocyte structural plasticity to brain function and behavior.
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星形胶质细胞诱导的突触发生的分子机制。
影响因子：
5.7
作者：
Baldwin KT;Eroglu C
通讯作者：
Eroglu C
影响因子：
5.3
作者：
Ben Haim L;Carrillo-de Sauvage MA;Ceyzériat K;Escartin C
通讯作者：
Escartin C
DOI：
10.1083/jcb.117.2.357
发表时间：
1992-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Baorto DM;Mellado W;Shelanski ML
通讯作者：
Shelanski ML
影响因子：
9.2
作者：
Bernardinelli, Yann;Randall, Jerome;Muller, Dominique
通讯作者：
Muller, Dominique
影响因子：
6.2
作者：
Arizono, Misa;Inavalli, V. V. G. Krishna;Nagerl, U. Valentin
通讯作者：
Nagerl, U. Valentin