Regenerative and Rehabilitative Medicine: A Necessary Synergy for Functional Recovery from Volumetric Muscle Loss Injury.
Regenerative and Rehabilitative Medicine: A Necessary Synergy for Functional Recovery from Volumetric Muscle Loss Injury.
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DOI：
10.1159/000444673
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Corona BT
中科院分区：
文献类型：
--
作者：
Greising SM;Dearth CL;Corona BT
体积肌肉损失（VML）是一个复杂的和异质性的问题，由于显着的创伤或手术损失的骨骼肌组织。VML的后果是关节活动范围和骨骼肌强度的实质性功能缺陷，导致终身功能障碍和残疾。传统的物理医学和康复模式没有解决由于VML和相关的肌肉骨骼共病引起的力损失的大小。再生医学的最新进展为VML损伤提出了令人鼓舞的和新兴的治疗选择。有显着的潜力，结合康复和再生治疗可以恢复肢体和肌肉功能后，VML损伤的协同方式。本文综述了VML领域的现状，涵盖临床和临床前文献，特别关注康复和再生医学以及它们的协同作用。展望未来，鼓励临床和研究领域之间的多学科合作，以继续改善VML损伤的治疗，并专门解决该患者人群的生理学，病理学和特定需求。
Volumetric muscle loss (VML) is a complex and heterogeneous problem due to significant traumatic or surgical loss of skeletal muscle tissue. The consequences of VML are substantial functional deficits in joint range of motion and skeletal muscle strength, resulting in life long dysfunction and disability. Traditional physical medicine and rehabilitation paradigms do not address the magnitude of force loss due to VML and related musculoskeletal co-morbidities. Recent advancements in regenerative medicine have set forth encouraging and emerging therapeutic options for VML injuries. There is significant potential that combined rehabilitative and regenerative therapies can restore limb and muscle function following VML injury in a synergistic manner. This review presents the current state of the VML field, spanning clinical and preclinical literature, with particular focus on rehabilitation and regenerative medicine in addition to their synergy. Moving forward, multidisciplinary collaboration between clinical and research fields is encouraged in order to continue to improve the treatment of VML injuries and specifically address the encompassing physiology, pathology, and specific needs of this patient population.
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影响因子：
3.9
作者：
Greising, Sarah M.;Carey, Ryan S.;Blackford, Jennifer E.;Dalton, Laurin E.;Kosir, Allison M.;Lowe, Dawn A.
通讯作者：
Lowe, Dawn A.
DOI：
10.1002/wsbm.1184
发表时间：
2012-09
影响因子：
7.9
作者：
Greising, Sarah M.;Gransee, Heather M.;Mantilla, Carlos B.;Sieck, Gary C.
通讯作者：
Sieck, Gary C.
影响因子：
--
作者：
ALWAY, SE;GONYEA, WJ;DAVIS, ME
通讯作者：
DAVIS, ME
DOI：
10.1186/2052-1847-6-41
发表时间：
2014
期刊：
BMC sports science, medicine & rehabilitation
影响因子：
--
作者：
Aurora A;Garg K;Corona BT;Walters TJ
通讯作者：
Walters TJ
DOI：
10.1016/j.bjps.2013.07.037
发表时间：
2013-12-01
影响因子：
2.7
作者：
Chen, Xiaoyu K.;Walters, Thomas J.
通讯作者：
Walters, Thomas J.