Systems biology of skeletal muscle: fiber type as an organizing principle.

Systems biology of skeletal muscle: fiber type as an organizing principle.
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DOI:
10.1002/wsbm.1184
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发表时间:
2012-09
影响因子:
7.9
通讯作者:
Sieck, Gary C.
Sieck, Gary C.
中科院分区:
医学3区
文献类型:
--
作者:
Greising, Sarah M.;Gransee, Heather M.;Mantilla, Carlos B.;Sieck, Gary C.

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骨骼肌力的产生和收缩是人类生活中无数方面的基础。骨骼肌生理学的复杂性被纤维类型分类所简化,其中观察到从神经肌肉传递到肌浆网释放细胞内钙离子以及由此导致的跨桥募集和循环的不同。该综述使用纤维类型分类作为组织和简化原则,以探索参与肌力产生和收缩的主要蛋白质之间的复杂相互作用。
Skeletal muscle force generation and contraction are fundamental to countless aspects of human life. The complexity of skeletal muscle physiology is simplified by fiber type classification where differences are observed from neuromuscular transmission to release of intracellular Ca2+ from the sarcoplasmic reticulum and the resulting recruitment and cycling of cross-bridges. This review uses fiber type classification as an organizing and simplifying principle to explore the complex interactions between the major proteins involved in muscle force generation and contraction.
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