Multiregional communication and the channel modulation hypothesis.

Multiregional communication and the channel modulation hypothesis.
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多区域通信与信道调制假说。

DOI:
10.1016/j.conb.2020.11.016
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发表时间:
2021-03
影响因子:
5.7
通讯作者:
Shewcraft R
Shewcraft R
中科院分区:
医学2区
文献类型:
--
作者:
Pesaran B;Hagan M;Qiao S;Shewcraft R

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多区域交流对于理解支持复杂行为的大脑机制很重要。动物和人类受试者的工作表明,多区域沟通在认知功能中起着重要作用,并且与脑功能的神经和神经精神疾病有关。最近的实验进步可以实现多区域通信机制的经验测试。对大脑网络功能的最新机械见解还提出了治疗无序大脑网络的新疗法。在这里,我们讨论了如何使用通信渠道调制的概念可以帮助定义和约束多区域通信的含义。我们讨论了多区域通道调节的行为和神经生理学证据。然后,我们考虑因果操纵的作用及其对基于多区域交流的新疗法的影响。
Multiregional communication is important to understanding the brain mechanisms supporting complex behaviors. Work in animals and human subjects shows that multiregional communication plays significant roles in cognitive function and is associated with neurological and neuropsychiatric disorders of brain function. Recent experimental advances enable empirical tests of the mechanisms of multiregional communication. Recent mechanistic insights into brain network function also suggest new therapies to treat disordered brain networks. Here, we discuss how to use the concept of communication channel modulation can help define and constrain what we mean by multiregional communication. We discuss behavioral and neurophysiological evidence for multiregional channels modulation. We then consider the role of causal manipulations and their implications for developing novel therapies based on multiregional communication.
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发表时间: 2015-10-07
期刊: Neuron
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