High-frequency, long-range coupling between prefrontal and visual cortex during attention.-猫眼课题宝

DOI：

10.1126/science.1171402

发表时间：

2009-05-29

期刊：

Science (New York, N.Y.)

影响因子：

通讯作者：

中科院分区：

其他

文献类型：

作者：

Gregoriou GG;Gotts SJ;Zhou H;Desimone R

来源链接：

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849291/?report=classic

在人类和猴子身上进行的电记录显示，腹侧通路皮质区域的诱发反应和伽马同步性在注意力集中时会增强。这种同步性是由视觉皮质的内在活动引起的，还是由其他结构的输入导致的呢？通过对额叶眼区（FEF）和V4区进行成对记录，我们发现，当注意力集中在它们共同的感受野内的一个刺激上时，这两个区域之间的振荡耦合会增强，尤其是在伽马频率上。这种耦合似乎是由额叶眼区发起的，并且在一系列频率上存在约8 - 13毫秒的时间偏移。考虑到这两个区域之间预期的传导和突触延迟，这种伽马频率下的时间偏移耦合可能会优化一个区域的神经元放电对另一个区域的突触后影响，从而在注意力集中时改善跨区域的信息交流。

Electrical recordings in humans and monkeys show attentional enhancement of evoked responses and gamma synchrony in ventral stream cortical areas. Does this synchrony result from intrinsic activity in visual cortex or from inputs from other structures? Using paired-recordings in the frontal eye field (FEF) and area V4, we found that attention to a stimulus in their joint receptive field leads to enhanced oscillatory coupling between the two areas, particularly at gamma frequencies. This coupling appeared to be initiated by FEF and was time-shifted by about 8-13 ms across a range of frequencies. Considering the expected conduction and synaptic delays between the areas, this time-shifted coupling at gamma frequencies may optimize the postsynaptic impact of spikes from one area upon the other, improving cross-area communication with attention.