Defining focal brain stimulation targets for PTSD using neuroimaging.
Defining focal brain stimulation targets for PTSD using neuroimaging.
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DOI：
10.1002/da.23159
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发表时间：
2021-04-20
影响因子：
7.4
通讯作者：
Holtzheimer PE
中科院分区：
文献类型：
--
作者：
van Rooij SJH;Sippel LM;McDonald WM;Holtzheimer PE
Focal brain stimulation has potential as a treatment for posttraumatic stress disorder (PTSD). In this review, we aim to inform selection of focal brain stimulation targets for treating PTSD by examining studies of the functional neuroanatomy of PTSD and treatment response. We first briefly review data on brain stimulation interventions for PTSD. Although published data suggest good efficacy overall, the neurobiological rationale for each stimulation target is not always clear. Therefore, we assess pre- and post-treatment (predominantly psychotherapy) functional neuroimaging studies in PTSD to determine which brain changes seem critical to treatment response. Results of these studies are presented within a previously proposed functional neural systems model of PTSD. While not completely consistent, research suggests that down-regulating the fear learning and threat and salience detection circuits (i.e., amygdala, dorsal anterior cingulate cortex and insula) and upregulating the emotion regulation and executive function and contextual processing circuits (i.e., prefrontal cortical regions and hippocampus) may mediate PTSD treatment response. This literature review provides some justification for current focal brain stimulation targets. However, the examination of treatment effects on neural networks is limited, and studies that include the stimulation targets are lacking. Further, additional targets, such as the cingulate, medial prefrontal cortex, and inferior parietal lobe, may also be worth investigation, especially when considering how to achieve network level changes. Additional research combining PTSD treatment with functional neuroimaging will help move the field forward by identifying and validating novel targets, providing better rationale for specific treatment parameters and personalizing treatment for PTSD.
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DOI：
10.1038/s41583-018-0039-7
发表时间：
2018-09
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Fenster RJ;Lebois LAM;Ressler KJ;Suh J
通讯作者：
Suh J
影响因子：
64.8
作者：
Ciocchi, Stephane;Herry, Cyril;Luethi, Andreas
通讯作者：
Luethi, Andreas
影响因子：
6.9
作者：
Bryant, R. A.;Felmingham, K.;Williams, L.
通讯作者：
Williams, L.
影响因子：
--
作者：
Fonzo GA;Federchenco V;Lara A
通讯作者：
Lara A
影响因子：
3
作者：
Dittert N;Hüttner S;Polak T;Herrmann MJ
通讯作者：
Herrmann MJ