Preventing urinary tract infection: progress toward an effective Escherichia coli vaccine.
Preventing urinary tract infection: progress toward an effective Escherichia coli vaccine.
复制标题
防止尿路感染：朝着有效的大肠杆菌疫苗迈进。
DOI：
10.1586/erv.12.36
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发表时间：
2012-06
影响因子：
6.2
通讯作者：
Mobley HL
中科院分区：
文献类型：
--
作者：
Brumbaugh AR;Mobley HL
简单的尿路感染（UTI）很常见，近一半的女性一生中至少经历过一次UTI。这种高频率的感染导致巨大的年度经济成本，劳动力生产率下降和患者发病率高。这些感染中至少80%是由尿路致病性大肠杆菌（UPEC）引起的。UPEC可以与尿道菌株并排存在于胃肠道中，并通过尿道的定植进入膀胱。抗生素代表了目前UTI的标准治疗;然而，即使在治疗后，患者也经常遭受相同或不同菌株的复发感染。此外，成功的长期治疗已复杂化的数量增加的耐药菌株和流行的耐药机制。因此，人们一直在寻求UTI的预防方法，如疫苗接种。本文综述了UPEC疫苗开发的最新进展，并概述了该领域的未来发展方向。
Uncomplicated urinary tract infections (UTIs) are common, with nearly half of all women experiencing at least one UTI in their lifetime. This high frequency of infection results in huge annual economic costs, decreased workforce productivity and high patient morbidity. At least 80% of these infections are caused by uropathogenic Escherichia coli (UPEC). UPEC can reside side by side with commensal strains in the gastrointestinal tract and gain access to the bladder via colonization of the urethra. Antibiotics represent the current standard treatment for UTI; however, even after treatment, patients frequently suffer from recurrent infection with the same or different strains. In addition, successful long-term treatment has been complicated by a rise in both the number of antibiotic-resistant strains and the prevalence of antibiotic-resistance mechanisms. As a result, preventative approaches to UTI, such as vaccination, have been sought. This review summarizes recent advances in UPEC vaccine development and outlines future directions for the field.
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影响因子：
3.1
作者：
Billips, Benjamin K.;Schaeffer, Anthony J.;Klumpp, David J.
通讯作者：
Klumpp, David J.
影响因子：
56.9
作者：
EISENSTEIN, BI
通讯作者：
EISENSTEIN, BI
影响因子：
6.4
作者：
Billips, Benjamin K.;Yaggie, Ryan E.;Klumpp, David J.
通讯作者：
Klumpp, David J.
影响因子：
5
作者：
Foxman, B;Gillespie, B;Marrs, CF
通讯作者：
Marrs, CF
影响因子：
15.9
作者：
Goluszko, P;Moseley, SL;Nowicki, B
通讯作者：
Nowicki, B