Targeting strategies of liposomal subunit vaccine delivery systems to improve vaccine efficacy
Targeting strategies of liposomal subunit vaccine delivery systems to improve vaccine efficacy
复制标题
脂质体亚单位疫苗递送系统的靶向策略以提高疫苗功效
DOI：
10.1080/1061186x.2018.1547734
复制
发表时间：
2019-08
影响因子：
4.5
通讯作者：
Jianhong Yang
中科院分区：
文献类型：
--
作者：
Rui Yu;Yaping Mai;Yue Zhao;Yanhui Hou;Yanhua Liu;Jianhong Yang
摘要脂质体是一种多功能的载体系统和免疫佐剂，它不仅可以负载蛋白质、多肽、核酸和糖类等多种抗原，而且可以将它们与免疫刺激剂联合收割机结合。脂质体在新型疫苗的开发中具有巨大的潜力，并且近年来已经致力于提高疫苗效力。不同类型的免疫细胞如巨噬细胞和树突细胞在免疫应答和预防或治疗癌症、过敏或许多其他感染性疾病中起重要作用。将基于脂质体的递送系统靶向某些免疫细胞和器官是此类治疗中最有效的措施之一。广泛的研究表明，脂质体与免疫刺激剂结合或用模式识别受体配体修饰可以靶向各种免疫细胞和淋巴系统，因此不仅诱导和促进所需的免疫应答，而且减少全身的不良反应，避免靶向不相关的细胞类型或组织。因此，在这篇综述中，我们概述了一些靶向策略，可以采用在脂质体疫苗的设计，以提高疫苗的效力，我们总结了相关的脂质体疫苗在几种疾病中的应用。这些应用在治疗或预防某些感染性和难治性疾病方面具有巨大的潜力。
Abstract Liposomes are versatile delivery systems and immunological adjuvants that not only can load various antigens, such as proteins, peptides, nucleic acids and carbohydrates, but also can combine them with immunostimulators. Liposomes have great potential in the development of new types of vaccines, and much effort has been devoted to enhancing vaccine efficacy in recent years. Different types of immune cells such as macrophages and dendritic cells play an important role in the immune response and in preventing or treating cancer, allergy or many other infectious diseases. Targeting liposome-based delivery systems to certain immune cells and organs is one of the most effective measures in such treatments. Extensive research has shown that liposomes combined with immunostimulators or modified with pattern recognition receptor ligands can target various immune cells and the lymphatic system, thus not only inducing and promoting the desired immune response but also decreasing adverse effects throughout the body and avoiding targeting irrelevant cell types or tissues. Therefore, in this review, we outline some targeting strategies that can be adopted in the design of liposomal vaccines to improve vaccine efficacy, and we summarise the related liposome-based vaccine applications in several diseases. These applications have great potential to treat or prevent some infectious and intractable diseases.
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影响因子：
5.5
作者：
Poderoso, Teresa;Martinez, Paloma;Revilla, Concepcion
通讯作者：
Revilla, Concepcion
影响因子：
3.7
作者：
Suzuki H;Watari A;Hashimoto E;Yonemitsu M;Kiyono H;Yagi K;Kondoh M;Kunisawa J
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影响因子：
5.5
作者：
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通讯作者：
Ofori-Anyinam, Opokua
影响因子：
10.8
作者：
Unger, Wendy W. J.;van Beelen, Astrid J.;van Kooyk, Yvette
通讯作者：
van Kooyk, Yvette
DOI：
10.1177/2051013614541440
发表时间：
2014-11-01
期刊：
Therapeutic advances in vaccines
影响因子：
--
作者：
Schwendener, Reto A
通讯作者：
Schwendener, Reto A