Molecular targets of dietary polyphenols with anti-inflammatory properties.
Molecular targets of dietary polyphenols with anti-inflammatory properties.
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DOI：
10.3349/ymj.2005.46.5.585
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发表时间：
2005-10-31
影响因子：
2.4
通讯作者：
Baek SJ
中科院分区：
文献类型：
--
作者：
Yoon JH;Baek SJ
有说服力的流行病学和实验证据表明，膳食多酚具有抗炎活性。阿司匹林和其他非类固醇抗炎药(NSAIDs)长期以来一直被用于抗炎。近年来，环氧合酶(COX)抑制剂已被开发并推荐用于治疗类风湿性关节炎(RA)和骨关节炎(OA)。然而，由于意想不到的副作用，两种COX抑制剂已从市场上撤出。由于传统的治疗和手术方法不能完全控制许多炎症性疾病的发病率和结局，迫切需要寻找更安全的化合物并开发基于机制的方法来管理这些疾病。多酚存在于许多食用植物产品中，包括水果、蔬菜、饮料、草药和香料。已发现其中几种化合物可以抑制实验动物的炎症过程和肿瘤形成；它们还可以显示出强大的生物学特性。此外，流行病学研究表明，食用富含特定多酚的食物的人群患炎症性疾病的几率较低。本文概述了可用于揭示多酚的生物学和健康影响的研究方法。多酚类物质具有多种生物学效应，但本文将重点介绍一些直接影响炎症过程的关键分子靶点。
There is persuasive epidemiological and experimental evidence that dietary polyphenols have anti-inflammatory activity. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) have long been used to combat inflammation. Recently, cyclooxygenase (COX) inhibitors have been developed and recommended for treatment of rheumatoid arthritis (RA) and osteoarthritis (OA). However, two COX inhibitors have been withdrawn from the market due to unexpected side effects. Because conventional therapeutic and surgical approaches have not been able to fully control the incidence and outcome of many inflammatory diseases, there is an urgent need to find safer compounds and to develop mechanism-based approaches for the management of these diseases. Polyphenols are found in many dietary plant products, including fruits, vegetables, beverages, herbs, and spices. Several of these compounds have been found to inhibit the inflammation process as well as tumorigenesis in experimental animals; they can also exhibit potent biological properties. In addition, epidemiological studies have indicated that populations who consume foods rich in specific polyphenols have lower incidences of inflammatory disease. This paper provides an overview of the research approaches that can be used to unravel the biology and health effects of polyphenols. Polyphenols have diverse biological effects, however, this review will focus on some of the pivotal molecular targets that directly affect the inflammation process.
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