Serum Glycerophospholipid Profile in Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
Serum Glycerophospholipid Profile in Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
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慢性阻塞性肺疾病急性加重时的血清甘油磷脂谱
DOI：
10.3389/fphys.2021.646010
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发表时间：
2021
影响因子：
4
通讯作者：
Chang C
中科院分区：
文献类型：
--
作者：
Gai X;Guo C;Zhang L;Zhang L;Abulikemu M;Wang J;Zhou Q;Chen Y;Sun Y;Chang C
研究表明，甘油磷脂参与慢性阻塞性肺疾病(COPD)的发病机制。本研究采用靶向代谢组学分析方法，探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清甘油磷脂的变化及其在不同炎症亚型患者中的差异表达。纳入2015年1月至2017年12月间收治的AECOPD患者，收集其临床资料。记录患者的性别、年龄、体重指数和肺功能。进行血常规和诱导痰检测。采用液-质联用技术检测血清甘油磷脂代谢谱，分析急性加重期与恢复期的代谢谱变化及不同炎症亚型之间的差异。AECOPD住院患者58例，其中男性49例，平均年龄74.8±10.0岁。在代谢谱中，溶血磷脂酰胆碱(LPC)18：3、溶血磷脂酰乙醇胺(LPE)16：1、磷脂酰肌醇(PI)32：1的表达在急性加重期明显低于恢复期(P<；0.05)。用3种甘油磷脂绘制受试者工作特征曲线预测急性加重/恢复期，曲线下面积均在70%以上。两组患者病情加重时血嗜酸性粒细胞百分率(EOS%)、≥2%和2%之间无差异代谢产物。血EOS+2%的炎性亚型急性加重期LPC 18：3、LPE 16：1、PI 32：1的表达明显低于恢复期(P<0.05)。甘油磷脂代谢异常可能与AECOPD的发病有关，尤其是在非嗜酸性粒细胞亚型。
Studies have shown that glycerophospholipids are involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study adopted targeted metabolomic analysis to investigate the changes in serum glycerophospholipids in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and their differential expression in patients with different inflammatory subtypes. Patients with AECOPD admitted between January 2015 and December 2017 were enrolled, and their clinical data were collected. The patients’ gender, age, body mass index, and lung function were recorded. Routine blood and induced sputum tests were performed. Liquid chromatography-mass spectrometry was used to detect the serum glycerophospholipid metabolic profiles and to analyze the metabolic profile changes between the acute exacerbation and recovery stages as well as the differences between different inflammatory subtypes. A total of 58 patients were hospitalized for AECOPD, including 49 male patients with a mean age of 74.8 ± 10.0 years. In the metabolic profiles, the expression of lysophosphatidylcholine (LPC) 18:3, lysophosphatidylethanolamine (LPE) 16:1, and phosphatidylinositol (PI) 32:1 was significantly reduced in the acute exacerbation stage compared to the recovery stage (P < 0.05). The three glycerophospholipids were used to plot the receiver operating characteristic curves to predict the acute exacerbation/recovery stage, and the areas under the curves were all above 70%. There were no differential metabolites between the two groups of patients with blood eosinophil percentage (EOS%) ≥2% and <2% at exacerbation. The expression of LPC 18:3, LPE 16:1, and PI 32:1 was significantly reduced in the acute exacerbation stage compared to the recovery stage in the inflammatory subtype with blood EOS <2% (P < 0.05). Abnormalities in the metabolism of glycerophospholipids may be involved in the onset of AECOPD, especially in the non-eosinophilic subtype.
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作者：
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发表时间：
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DOI：
10.1016/j.bbalip.2012.07.019
发表时间：
2013-01-01
影响因子：
4.8
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Aidinis, Vassilis