Selective coupling between theta phase and neocortical fast gamma oscillations during REM-sleep in mice.
Selective coupling between theta phase and neocortical fast gamma oscillations during REM-sleep in mice.
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DOI：
10.1371/journal.pone.0028489
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Brankačk J
中科院分区：
文献类型：
--
作者：
Scheffzük C;Kukushka VI;Vyssotski AL;Draguhn A;Tort AB;Brankačk J
哺乳动物的大脑表达了广泛的状态依赖网络振荡，其频率和空间扩展变化。这种节律可以使多个神经元进入连贯的活动模式，与行为、认知和记忆形成中的作用一致。最近的证据表明，局部产生的快速网络振荡可以系统地与长期缓慢振荡对齐。这种交叉频率耦合很可能支持特定的任务，包括行为选择和工作记忆。我们分析了小鼠顶叶新皮层记录的高频振荡和脑电图θ活动（4-12 Hz）之间的时间耦合。θ波只在清醒和快速眼动睡眠时出现。快速振荡发生在两个独立的频段：伽马（40-100赫兹）和快速伽马（120-160赫兹）。与快速眼动睡眠相比，活跃清醒状态下的θ波、伽马波和快速伽马波更为突出。然而，在快速眼动睡眠期间，θ波和两种快速振荡之间的耦合更为明显。这种状态依赖的交叉频率耦合在快速伽马相互作用中尤为强烈，在快速眼动期间比清醒状态增加了9倍。θ - γ耦合只增加了1.5倍。状态相关的交叉频率耦合为快速眼动睡眠提供了一种新的功能特征，并建立了新皮层快速伽马振荡的独特特性。定义的慢速和快速网络振荡模式之间的相互作用可能在睡眠依赖的信息处理中具有选择性功能。
The mammalian brain expresses a wide range of state-dependent network oscillations which vary in frequency and spatial extension. Such rhythms can entrain multiple neurons into coherent patterns of activity, consistent with a role in behaviour, cognition and memory formation. Recent evidence suggests that locally generated fast network oscillations can be systematically aligned to long-range slow oscillations. It is likely that such cross-frequency coupling supports specific tasks including behavioural choice and working memory. We analyzed temporal coupling between high-frequency oscillations and EEG theta activity (4–12 Hz) in recordings from mouse parietal neocortex. Theta was exclusively present during active wakefulness and REM-sleep. Fast oscillations occurred in two separate frequency bands: gamma (40–100 Hz) and fast gamma (120–160 Hz). Theta, gamma and fast gamma were more prominent during active wakefulness as compared to REM-sleep. Coupling between theta and the two types of fast oscillations, however, was more pronounced during REM-sleep. This state-dependent cross-frequency coupling was particularly strong for theta-fast gamma interaction which increased 9-fold during REM as compared to active wakefulness. Theta-gamma coupling increased only by 1.5-fold. State-dependent cross-frequency-coupling provides a new functional characteristic of REM-sleep and establishes a unique property of neocortical fast gamma oscillations. Interactions between defined patterns of slow and fast network oscillations may serve selective functions in sleep-dependent information processing.
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影响因子：
2.9
作者：
Brankack, Jurij;Kukushka, Valeriy I.;Draguhn, Andreas
通讯作者：
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3
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影响因子：
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作者：
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通讯作者：
BUZSAKI, G
影响因子：
--
作者：
Berger, H
通讯作者：
Berger, H