Exposure to an inflammatory challenge enhances neural sensitivity to negative and positive social feedback.
Exposure to an inflammatory challenge enhances neural sensitivity to negative and positive social feedback.
复制标题
DOI：
10.1016/j.bbi.2016.03.022
复制
发表时间：
2016-10
影响因子：
15.1
通讯作者：
Eisenberger, Naomi I.
中科院分区：
文献类型：
--
作者：
Muscatell, Keely A.;Moieni, Mona;Inagaki, Tristen K.;Dutcher, Janine M.;Jevtic, Ivana;Breen, Elizabeth C.;Irwin, Michael R.;Eisenberger, Naomi I.
炎症是人体先天免疫反应的一部分，可导致“疾病行为”，以及社交和情感体验的改变。促炎细胞因子水平的升高与神经对社会拒绝和社会威胁的敏感性增加有关，但也降低了神经对奖励的敏感性。然而，最近的证据表明，炎症实际上可能会增强人们对某些社会奖励的敏感性，比如那些表示支持和关心的奖励。尽管人们对炎症如何影响神经对积极和消极社会体验的反应性越来越感兴趣，但目前还没有已知的研究使用类似的任务在相同的参与者中调查这些过程。为了研究这一问题，107名参与者被随机分配接受安慰剂或低剂量内毒素，后者安全地触发炎症反应。当促炎细胞因子水平达到顶峰时，参与者接受了fMRI扫描，同时他们从一名“评估者”(实际上是南部邦联成员)那里收到了关于他们在录音采访中的印象的积极、负面和中性的反馈。与安慰剂组参与者相比，处于内毒素状态的参与者对负反馈(与中性反馈相比)在许多威胁相关神经区域(即双侧杏仁核、扣带回背侧前扣带皮质)和一个关键的脑化相关区域(即背内侧PFC)显示出更高的神经活性。有趣的是，与安慰剂相比，当接受正反馈(与中性反馈相比)时，内毒素导致腹侧纹状体和腹内侧PFC的神经活动更强，这两个区域通常与处理奖赏有关。总而言之，这些结果表明，暴露在炎症性挑战中的个人对负面和积极的社会反馈都更“神经敏感”，这表明炎症可能会导致对社会威胁和社会回报的更高警觉。
Inflammation, part of the body’s innate immune response, can lead to “sickness behaviors,” as well as alterations in social and affective experiences. Elevated levels of pro-inflammatory cytokines have been associated with increased neural sensitivity to social rejection and social threat, but also decreased neural sensitivity to rewards. However, recent evidence suggests that inflammation may actually enhance sensitivity to certain social rewards, such as those that signal support and care. Despite a growing interest in how inflammation influences neural reactivity to positive and negative social experiences, no known studies have investigated these processes in the same participants, using a similar task. To examine this issue, 107 participants were randomly assigned to receive either placebo or low-dose endotoxin, which safely triggers an inflammatory response. When levels of pro-inflammatory cytokines were at their peak, participants were scanned using fMRI while they received positive, negative, and neutral feedback from an “evaluator” (actually a confederate) about how they came across in an audio-recorded interview. In response to negative feedback (vs. neutral), participants in the endotoxin condition showed heightened neural activity in a number of threat-related neural regions (i.e., bilateral amygdala, dorsal anterior cingulate cortex) and a key mentalizing-related region (i.e., dorsomedial PFC), compared to placebo participants. Interestingly, when receiving positive feedback (vs. neutral), endotoxin led to greater neural activity in the ventral striatum and ventromedial PFC, regions often implicated in processing reward, compared to placebo. Together, these results reveal that individuals exposed to an inflammatory challenge are more “neurally sensitive” to both negative and positive social feedback, suggesting that inflammation may lead to a greater vigilance for both social threats and social rewards.
登录
查看更多内容
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
影响因子：
11
作者：
O'Connor, J. C.;Lawson, M. A.;Dantzer, R.
通讯作者：
Dantzer, R.
影响因子：
--
作者：
Reichenberg, A;Yirmiya, R;Pollmächer, T
通讯作者：
Pollmächer, T
影响因子：
10.6
作者：
Harrison NA;Brydon L;Walker C;Gray MA;Steptoe A;Critchley HD
通讯作者：
Critchley HD
影响因子：
--
作者：
Capuron L;Pagnoni G;Drake DF;Woolwine BJ;Spivey JR;Crowe RJ;Votaw JR;Goodman MM;Miller AH
通讯作者：
Miller AH