Are women with polycystic ovarian syndrome at a high risk of non-alcoholic Fatty liver disease; a meta-analysis.
Are women with polycystic ovarian syndrome at a high risk of non-alcoholic Fatty liver disease; a meta-analysis.
复制标题
DOI：
10.5812/hepatmon.23235
复制
发表时间：
2014-11
影响因子：
0.6
通讯作者：
Alavian SM
中科院分区：
文献类型：
--
作者：
Ramezani-Binabaj M;Motalebi M;Karimi-Sari H;Rezaee-Zavareh MS;Alavian SM
胰岛素抵抗是代谢综合征（MS）的一个标志。多囊卵巢综合征（PCOS）和非酒精性脂肪性肝病（NAFLD）均与胰岛素抵抗相关。因此，PCOS和NAFLD可以归因于胰岛素抵抗，因此MS。这项荟萃分析的目的是确定PCOS患者是否处于NAFLD的高风险中。检索了Google scholar、Scopus、ISI Web of Science、Embase、MEDLINE和一些伊朗数据库，如科学信息数据库（SID）、IranMedex和MagIran，以识别相关研究。我们纳入了从1985年1月到2013年6月的所有论文，无论其语言如何。通过使用PCOS患者和非PCOS患者NAFLD患病率的数据，计算每项研究中的比值比（OR）和95%置信区间（CI）。卡方检验用于评估研究之间的异质性。我们最终纳入了7项符合条件的研究。经卡方检验，研究间存在显著异质性（73.6%）（P = 0.001）。PCOS患者NAFLD患病率显著高于健康对照组，总OR为3.93（95%CI：2.17，7.11）。根据这项荟萃分析的结果，PCOS女性患NAFLD的风险很高。我们建议评估PCOS患者的NAFLD。
Insulin resistance is a hallmark of metabolic syndrome (MS). It has been proposed that both polycystic ovarian syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD) are correlated with Insulin resistance. Therefore, PCOS and NAFLD can be attributed with insulin resistance and therefore MS. The aim of this meta-analysis was to determine whether PCOS patients are at a high risk of NAFLD. Google scholar, Scopus, ISI Web of Science, Embase, MEDLINE, and some Iranian databases such as scientific information database (SID), IranMedex, and MagIran were searched to identify relevant studies. We included all papers regardless of their language from January 1985 to June 2013. By using data on prevalence of NAFLD in patients with and without PCOS, odds ratio (OR) with 95% confidence intervals (CIs) were calculated in each study. Chi-squared test was used to assess heterogeneity between studies. We finally included seven eligible studies. According to chi-squared test, there was a significant heterogeneity (73.6%) between studies (P = 0.001). NAFLD prevalence was significantly higher in patients with PCOS compared to healthy control, with an overall OR of 3.93 (95% CI: 2.17, 7.11).There was no significant publication bias based on Begg's and Egger's tests. According to the results of this meta-analysis, there was a high risk of NAFLD in women with PCOS. We suggest evaluating patients with PCOS regarding NAFLD.
登录
查看更多内容
DOI：
10.1111/j.1440-1746.2008.05740.x
发表时间：
2009-02-01
影响因子：
4.1
作者：
Brzozowska, Malgorzata M.;Ostapowicz, George;Weltman, Martin D.
通讯作者：
Weltman, Martin D.
影响因子：
5.4
作者：
Targher, G.;Solagna, E.;Moghetti, P.
通讯作者：
Moghetti, P.
影响因子：
6.1
作者：
Vassilatou, E.;Lafoyianni, S.;Tzavara, I.
通讯作者：
Tzavara, I.
影响因子：
4.3
作者：
Jamali, Raika;Khonsari, Mahmoodreza;Pourshams, Akram
通讯作者：
Pourshams, Akram
影响因子：
25.7
作者：
Angulo, P;Alba, LM;Jensen, MD
通讯作者：
Jensen, MD